利用炔酮化合物合成3-烯丙基黄酮衍生物及苯偶酰衍生物的方法学分析-化学专业论文.docxVIP

Abstract Abstract 万方数据 万方数据 Abstract Unsaturated Alkynone compounds are a kind of important structural unit, which are widely used as key intermediates in the synthesis of a variety of complex organic compounds such as drug, dye and conductor materials. 3-allyl-chromone, exists in bean and mulberry, is a privileged structural scaffold for drug discovery due to its significant biological activities in vitro and in vivo, which results in the importance of efficient synthetic methods to build such structures. We design a concise and efficient strategy for the synthesis of 3-allylchromones via a tandem reaction including Michael addition, Claisen rearrangement and Ullmann-type O-arylation in one pot under metal-free conditions and a plausible reaction mechanism is proposed. Generally, in this procedure, the noble metal (gold or palladium) is necessary and the starting materials are difficult to prepare. We synthesize a series of 3-allyl-chromones derivatives under mild conditions by a simple and effective method. α-diketone derivatives are great importance of precursors that have been proposed as versatile building blocks for the synthesis of pharmaceutical agents and functional materials. Therefore, substantial efforts for the development of efficient synthetic strategies towards these targets have been undertaken. We report a novel and environmentally friendly method as complement for the preparation of α-diketones by oxidative C-C bond cleavage of alkynones under atmospheric oxygen and a plausible reaction mechanism is proposed. In this paper, 3-allyl-chromone and α-diketone derivatives are synthesized under mild conditions. In this procedure, raw materials are availability, transition metal is not necessary and operation is simple. This method is environmental friendly, low carbon economical, and has a wide application prospect. Keywords: 3-allyl-chromone α-diketone tandem reaction oxidization II 目录 目录 目录 第 1 章 引言.....................................................