两个双等位基因位点之间的交互作用-概率论与数理统计专业论文.docxVIP

当上述四个相乘模型同时成立时，这两个位点之间存在统计学相乘交互作用，但 当上述四个相乘模型同时成立时，这两个位点之间存在统计学相乘交互作用，但 并不意味着不存在生物学交互作用；但是当上述四个相乘模型有一个不成立或多 个同时不成立时，则这两个位点之间不存在统计学相乘交互作用，必然存在生物 学交互作用， 第二类相乘模型有四个，如下， 珊07r11 丌007r12 1 ， 可bl丌10 7r02丌10 堡翌：1，旦丝：1． 仉l”20 丌02”20 当上述四个相乘模型同时成立时，这两个位点之间存在统计学相乘交互作用，但 并不意味着存在生物学交互作用；但是当上述四个相乘模型有一个不成立或多个 同时不成立时，则这两个位点之间不存在统计学相乘交互作用，必然存在生物学 交互作用． 关键词；归因危险度；极大熵；协同作用；混合作用；平行作用；可加交互作 用；相乘交互作用 II AbstractThe Abstract The concept of attributable risk for one and two binary exposure factors is reviewed and then extend to two biallelic loci．The concept of synergistic，parallel and two other kinds ofjoint action beteen the two factors are reviewed．Synergistic， parallel，migmatisation and four other kinds ofjoint action between the two bialMic loci are defined，and it iS shown how to estimate the amounts of actiolm of each kind． The additive and multiplicative models of no interaction are freshly interpreted in terms of synergistic，parallel and miginatisation action． 0nly the population with disease genes are concerned．The interactions bc— tween two biallelic loci are defined detailed．The joint penetrance and risk is de血ed．It iS shown how to estimate the ten parameters．The additive and mul- tiplicative models of no interaction are freshly interpreted in terms of synergistic， parallel and migmatisation action Four additive models of no interaction are de． nned as below． 7111—710—701+珊02 0，712一“02一”10+7002 0 7r21一”01一丌20+珊o=0，722—720～7r02+70D2 0． W1nell all of the fonr models are satisfied．there iS statistical additivc interaction between the two loci，but it is not surc whether biological interation exists between the two loci，When some or all of the four models are not satisfied，there is biolog- ical interation between the two loci definitely,and statistical additive interaction scarcely exists between the two the loci． Two types of multiplicative models of no interactions arc defined．One is deftned from health．shown a5 below． 丌i丽冈叫’F二面而刮’(1—700)(1—7111) ， (1一r00)(1—712) ． !!二婴塑二