狼疮静颗粒对活动性SLE细胞粘附分子-1表达的实验和临床分析-中医内科学专业论文.docxVIP

简历姓 简历 姓 名： 丁炜 性别：男 出生年月： 1966年2月 籍贯：江苏如皋 工作学习简历： 2000年9月一今天 南京中医药大学中医内科博士生 1996年8月--2000年9月 南京中医药大学助理研究员 1993年9月一1996年7月 南京中医药大学中药药理硕士生 1990年8月一1993年8月 南京江浦中医院内科住院医师 1985年9月一1990年7月 南京中医学院中医系学生 RESUME Name：Wei Ding Sex：Male Birth：February．1 966 Native Place：Rugao．Jiangsu province Educational and Professional Experience： 2000 9-presant Doctor student of Internal Medicine。Nanjing University of TCM 1 996．8—2000 9 Reseamh Assistant，Nanjing University of TCM 1 993．9—1 996．7 Master student of Pharmacology of Chinese Medicine，Nanjing University of TCM 1 990．8—1 993．8 Physician．Jiangpu hospital of TCM 1 985．9．1 990．7 Bachelor of Medicine，Nanjing College of TCM 南京中医药大学博士学位论文·摘要Abstract 南京中医药大学博士学位论文·摘要 Abstract Systemic lupus erythematosus(SLE)is an autoimmune disease with specificity caused by vanous factors．Its incidence rate 1s 70．4 1n 1 00 thousand in our country．and that of women from report attains 1 15 in 100 thousand．The disease．with chronic clinicaI duration，whose recurrence and remission exchange， affects every organ system．Renal failure．infection and damage of central nervous system are its undedying cause of death，which seriously threaten patients’health and Iife．SLE Is one of the d而cuIt problems in medical field．‘Langchuangjing Granule’(LG)is an effective preparation from pure chinese hedos in treating SLE． On the basis of fo肿er research．this paper proceeded research from expenment and clinic．regarded intercellular adhesion molecule(ICAM一1 or CD54)as Cardinal observe object，and tried to expatiate on its approach，tache and target． The experimentaI research consisted of two parts： pharmacologyandtoxicologystudies．Inpharmacologyresearch， lnbom NZB^～F1fNZB7N舀～F1 or Bw)1upus-prone mice were choosed to examine the expression of ICAM-1 in serum． peripheral blood lymphocyce and monocyte and kidney respectively．The results showed that in female NZBNV F1 mice of 3 month．the serum IeveI of soluable intercelluiar adhesion molecule一1(slCAM-1)was in the normal range，without