课件：抗血小板治疗争议与选择.pptVIP

Reference: 1. Jarvis B, Simpson K. Drugs 2000; 60: 347–77. Clopidogrel is a potent, non-competitive inhibitor of adenosine diphosphate- (ADP) induced platelet aggregation, irreversibly inhibiting the binding of ADP to its platelet membrane receptors. Consequently, platelets exposed to clopidogrel are affected for the remainder of their lifespan (approximately 7–10 days). The inhibition is specific and does not significantly affect cyclo-oxygenase (COX) or arachidonic acid metabolism. Clopidogrel can also indirectly inhibit platelet aggregation induced by agonists other than ADP by blocking the