山梨酸、肉桂酸、烟酸类芳杂环衍生物的合成与生物活性研究-农药学专业论文.docxVIP

堂竺生兰墨堕堕竺!兰堡堡兰摘要 堂竺生兰墨堕堕竺!兰堡堡兰 摘要 以商活性天然植物源成分为前体进行绿色农药的”发是2l世纪研究的热点课 题。本课题致力j；采厨具有天然活性的植物源成分山梨酸、肉桂酸、烟酸的硫脲或酰 胺类化合物的设计合成及生物活性研究，并取得了r些具有一定学术意义和应用前景 的创新性结果。 设计合成了杂环酰胶类新化台物8个，酰基芳环或杂环硫脲系列新化合物12个， 酰基含氟硫脲新化合物4个。并在此基础上通过了核磁共振氢谱、碳谱、红外光谱、 和元素分析的结构鉴定。深入地研究了合成硫脲类化合物的三种方法：直接硫脲化法、 相转移催化法、离子液体为溶剂的方法。优化了反应条件。实现了简便、高效的合成。 特别可贵的是研究了离子液体条件下硫脲类化合物的合成，实现了一条简便、有 效、。快速、合乎绿色化学原则的合成酰基硫脲类化合物的新方法。该法与经典合成方 法相比，缩短了反应时间，目标化合物的收率也得到一定程度的提高。 为了验证设计思想，我们将部分目标化合物进行了生物活性铡定。结果表明所有 化合物对小麦赤霉病菌和半夏枯萎病菌都有一定的抑翎活性， 关键词：山梨酸，肉桂酸，烟酸，酰胺，硫脲，PEG_600，离子液体，合成，生物活 性 贵州大学200s届硕士学位论文Abstract 贵州大学200s届硕士学位论文 Abstract In me 21st centllryit is a hoI field that the searcheS brillg me devel叩men￡0f green pesticides into focus employing锄d usillg Ihe active constitIIe壬its of且atIlral plants as raw materials．r11lis咖ef iS iIltended to explore the synmcsis and bioacti“ty of hetefocylic amide and acyl thiourea fIDm sorbic acid， dnn锄ic acid and nicotinic acid and sludy on their bioactivities．A series of usefLll and creative results、№re obtained 24 target new compounds haVe becn synthes谊ed induding eight comp伽nds of hetefocylic amide，sixteen di鼠reIlt co m_pounds of acyl thioufea．E1emental analysis was conduct酣and me stmctllres of the ncw compounds were teSted and confifIIled by 1H NMR、13C NMR and瓜 spectra． We have sttldied three methods of synthesizing the di船rent compounds of acyl lhiollrea coInprehensively，optiIllized the reatction conditions and conducted me simplest，most eff色ctive synthesis． The syntlilesis of acyl thiourea under the conditions of Ionic liquid is espccially salien乞in lhe research．A new，simple，e￡6巳ctive and quick method to synthesis them following the priIlciples of green chemistry h弱been found out．Comparing to the traditional methods of synlhesiS，the脚0ne shonened the reaction time and imp‘roved the yields of the end compounds to somc extend． 皿e part ta珞et compOllnds of preliminary investigation on the bioactivity have been carried out to tes￡our designs．The results of biological activity teSt indicated that some