慢性乙型肝炎患者血清免疫球蛋白水平的变化及临床意义-海南医学.PDFVIP

Hainan Med J, Dec. 2013, Vol. 24, No. 23 海南医学2013年12月第24卷第23期 doi:10.3969/j.issn.1003-6350.2013.23.1458 ·论 著· 慢性乙型肝炎患者血清免疫球蛋白水平的变化及临床意义 宋 莉 （达州市中西医结合医院检验科，四川 达州 635000） 【摘要】 目的 探讨慢性乙肝患者血清免疫球蛋白水平变化及其临床意义。方法 采用免疫比浊法对我 院2010 年1月至2012 年1月收治的100例乙型肝炎患者[其中慢性乙肝（CHB ）患者53 例、慢性重型乙肝（SHB）患 者47 例]及同期50 例健康体检者(健康对照组) 的血清免疫球蛋白（IgG、IgA 和IgM ）进行检测，比较各组患者免疫 球蛋白水平。结果 CHB 组与SHB 组患者IgG、IgA 和IgM 水平均明显高于健康对照组，且SHB 组免疫蛋白水 平明显高于CHB 组，差异均具有统计学意义（P0.05 ）；病情改善组IgG、IgA 和IgM 水平均明显低于恶化组，且两 组均较治疗前显著变化，差异均具有统计学意义（P0.05 ）。结论 血清免疫球蛋白水平能反映慢性乙肝患者肝 细胞受损程度，可为临床诊断、治疗和预后提供检测依据。 【关键词】 慢性乙型肝炎；免疫球蛋白；临床诊断 + 【中图分类号】 R512.6 2 【文献标识码】A 【文章编号】 1003—6350（2013 ）23—3509—03 ChangesofserumimmunoglobulinlevelsinpatientswithchronichepatitisBandtheirclinicalsignificance. SONGLi.DepartmentofClinicalLaboratory,DazhouHospitalofIntegratedTraditionalChineseandWesternMedicine, Dazhou635000,Sichuan,CHINA 【Abstract】 Objective To investigate the changes of serum immunoglobulin levels in patients with chronic hepatitis B and their clinical significance. Methods The serum immunoglobulin (IgG, IgA, and IgM) of 53 chronic hepatitis B patients (CHB group), 47 chronic severe hepatitis B patients (SHB group) and 50 healthy individuals (the control group) in our hospital from January 2010 to 2012 January were detected, and the immunoglobulin levels were compared between the three groups. Results IgG, IgA and IgM levels of CHB group and SHB group were signifi- cantly higher than those of the control group, and the immune proteins of SHB group was significantly higher than those of CHB group, all with statistically significant difference (P0.05). The IgG, IgA and