早期应用INSURE技术及肺表面活性物质防治早产儿肺出血的疗效探讨.docVIP

早期应用INSURE技术及肺表面活性物质防治早产儿肺出血的疗效探讨 (广东省屮山市屮医院广东屮山528400) 【摘 要】目的探讨早期应用INSURE技术及肺表面活性物质防治早产儿 肺出血屮的作用及效果。方法回顾性分析2006年1月?2014年12月屮山市屮 医院和佛山市顺德区妇幼保健院NICU收治的的485例高危早产儿临床资料，按 照是否按照是否早期应用INSURE技术及肺表面活性物质为防治组和对照组，比 较两组发生肺出血比例及预后。结果两家医院485例高危早产儿均有使用肺表 面活性物质及机械通气指征，其屮防治组227例，出生后0.5-2小时内采用INSURE 技术及肺表面活性物质，对照组258例釆用常规机械通气治疗，确诊NRDS再使 用肺表面活性物质，结果防治组和对照组肺出血发病率分别为2?64%(6/227)、 8.53%(22/258),有显著性差异(P0.05),并且两组早产儿机械通气初始吸氧浓 度、初始峰压、平均机械通气时间、住院时间及死亡率相比较，均有显著性差异 (PV0.05)。结论早期应用INSURE技术及肺表面活性物质能显著降低早产儿 肺出血的发病率，明显缩短平均机械通气时间和住院时间，提高早产儿肺出血的 治愈率，降低死亡率，并提高其生存质量。 【关键词[INSURE技术；肺表面活性物质；早产儿；肺出血 R722.6 A 1004-6194 (2015) 02-0420-02 [Abstract] Objective to study the preventive effect of of premature infant pulm on ary hemorrhage in early using INSURE tech no logy and pulm on ary surfactant ? Method Retrospective analysis of the clinical data of premature infant treated in our hospital and hospital of women and childcare center of Shunde, Foshan, from January 2006 to December 2014,divided them into the treatment group and the control group according to whether using INSURE technology and pulm on ary surfacta nt in treatme nt courses, compared the d iff ere nee in cide nee of pulm on ary hemorrhage an dthe prognosis of the two groups. Result Total 485 of two hospitals of premature infant used pulm on ary surfacta nt and mecha nical ven tilati on features during the study, and all cases were divided into the treatment group and the control group randomly. the treatment group have 227 cases, using INSURE tech no logy and pulm on ary surfacta nt to treat from 0.5h to 2h after birth, and the con trol group have 258 cases, using pulm on ary surfacta nt and conventional mecha nical ven tilation to treat after birth. The incide nee of pulm on ary hemorrhage of two groups were 2.64%(6/227)and8.53%(22/258), there was a significant difference (P lt;0.05).besides, there were significant differences(Plt;0.05) between the two groups in the early FiO2 of mechanical ventilation, the early PIP of mechanical ventila