沙美特罗替卡松粉吸入剂联合噻托溴铵粉雾剂治疗支气管哮喘的临床疗效分析.docVIP

沙美特罗替卡松粉吸入剂联合嗟托漠鞍粉雾剂治疗支气管哮喘的临床疗效分析 方靖 西安市第九医院老年病一科 陕西 西安 710054 【摘要】 目的 探讨沙美特罗/替卡松粉吸入剂联合卩塞托漠钱粉雾剂治疗 支气管哮喘的临床疗效及不良反应?方法 选择9 0例在本院接受支气管哮喘治 疗的患者随机分为实验组和对照组，每组各4 5例?对照组采用常规治疗,实验组 在常规治疗基础上给予沙美特罗/替卡松粉吸入剂联合卩塞托漠镀粉雾剂治疗?观 察比较两组临床疗效及相关指标?结果 实验组总有效率、显效率分别为9 7?7 8 %(4 4/4 5)和 6 2. 2 2 %( 2 8/4 5),明显高于对照组80. 0%(36/ 4 5)和3 3. 3 3 %( 1 5/4 5),差异具有统计学意义(P 0 . 0 5).与治疗前相 比，两组治疗后PEF、FEV 1均升高，嗜酸性粒细胞和IgE含量均降低，但实验组PEF、 FEV 1升高幅度和嗜酸性粒细胞、IgE含量降低幅度均高于对照组，差异有统计学 意义(P0. 0 5).结论 沙美特罗/替卡松粉吸入剂联合嗟托澳钱粉雾剂治疗支 气管哮喘具有较好的临床疗效，能明显缓解症状，不良反应轻，值得在临床上推广 使用.【关键词】 沙美特罗替卡松粉吸入剂;嗟托澳镀;粉雾剂;支气管哮喘;疗效 【Abstract] Objective Toexaminetheclinicalcurativeeffecta ndsideeffectsofSalmeteroIXin afoatea ndFluticas on ePropio natepowderforl nhalationcombinedwithThi G amethoxamJoebromidepowdermistonbronchialasthma. Methods 9 0 patie ntswithbr on chialasthmawerera ndomlydividedintotheexperime ntalgroupa ndthe controlgroup,eachgrouphad 4 5 patients. Theexperimentalgroupweretreatedwiththiamethoxambromidepowderato mizati on treatme ntofmist on thebasisofc onvention altreatG ment,thec on trolgroupweretreatedbyrouti netherapy. Themutuali ndexa nd efficacy oft wogroupsofpatientswerecompared. Results Totaleffectiverateandefficie ncyin theexperimentalgroupweresignifica ntlybettertha nth atinthecontrolgroup( 9 7. 7 8 %vs? 80. 0 %and 6 2 . 2 2 %vs? 33. 3 3 %?respectively,P 0 ? 0 5). PEFandFEV 1 wereinG creasedwhileeosi nophils nu mbera ndserumlgElevelswerereducedinbothgroups’whilet hera ngeofi ncreasi ngan dreduci ngperce ntagei nexperimentalgrouparesignifiG cantlyhigherthanthatineontrolgroup(P 0? 0 5). Conclusion SalmeteroIXinafoatea ndFluticas on ePropi on atepowderforl nhalati on combi nedwithThi amethoxamJoebro G mide ［ pKoewydewrormdiss］ tisworthytousedinclinic,asit??sgoodeffectstoimprovesymptomsa ndlesssideeffects onb ron chialasthma. SalmeteroIXinafoatea ndFluticas on ePropi on atepowderforl nhalatio nThiamethoxamJoebromide;Pinkmist;Bronchialasthma;curativeeffect【中图分类号］ R 5 6 2 . 2 【文献标识码】B 【文章编号】1 0 08 — 63 1 5 ( 2 0 1 5 ) 1 2-0572