快眼动睡眠剥夺对抑郁模型大鼠脑内5-羟色胺转运体和去甲肾上腺素转运体的影响-精神病与精神卫生学专业论文.docxVIP

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快眼动睡眠剥夺对抑郁模型大鼠脑内5-羟色胺转运体和去甲肾上腺素转运体的影响-精神病与精神卫生学专业论文.docx

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汕头大学医学院硕士研究生汕头大学医学院硕士研究生毕业论文 PAGE PAGE VI was analyzed by one-way analysis of variance (ANOVA), T test with SPSS11.0 for Windows and Excel 2000. All the value in text and figure was expressed as Mean ±Standard Deviation ( x ±S) or Mean ±Standard Error (x ±SE). Results: Animal behavior analysis system showed that the total activity was reduced after 21 days stresses(P =0.000), while 72 hours REM sleep deprivation reversed this effec（t P=0.010）. The total activity was reduced again after 48 hours recovering sleep compared with REMSD group （P=0.001）. The expression of SERT mRNA in midbrain was significantly decreased in depression model group compared with control group (P=0.017). The expression of NET mRNA in pons was significantly decreased in depression model group compared with control group (P=0.004). There was no expression of SERT mRNA and NET mRNA using the RT-PCR in frontal cortex, hippocampus and hypothalamus of the normal control rats and chronic stress rats. The expression of SERT mRNA in midbrain was significantly decreased in REMSD group compared with chronic stress group (P=0.027). The expression of SERT mRNA in midbrain was significantly increased after 48 hours recovering sleep compared with REMSD group（P=0.001）. The expression of NET mRNA in pons was significantly increased in REMSD group compared with chronic stress group (P=0.001). There was no difference in the expression of NET mRNA between 72 hours REM sleep deprivation and 48 hours recovering sleep group and REMSD group（P=0.608）. Conclusions: Rats showed depressive-behaviors after 21 days stresses, while 72 hours REM sleep deprivation could reverse this effect. It suggested that decreased expression of SERT mRNA in midbrain and NET mRNA in pons might be associated with the etiology of depressive disorder. It showed that decreased expression of SERT mRNA in midbrain and increased expression of NET mRNA in pons might be an important role in the antidepressant effects of sleep deprivation. It