五年制《医学免疫学》4主要组织相容性复合体.ppt

阴性选择 (negative selection) TCR MHC/自身Ag肽→凋亡 TCR MHC/自身Ag肽→存活 主要由胸腺髓质树突状细胞介导 意义：清除自身反应T细胞（auto-reactive T cell，ART），即指与MHC-自身Ag肽呈高度亲和力的T细胞。 高亲和力 低亲和力 或不识别 清除自身反应性（有害）T细胞 经阳性选择的T细胞与髓质DC和巨噬细胞提呈的自身肽/MHC复合物高亲和力结合，则发生凋亡。 3) MHC is the crucial determinant of disease susceptibility in different individuals 4) MHC contributes to the genetic heterogeneity of the population 2. Participate in the innate immunity serving as regulatory molecules Classical MHC class III genes encode complement, hereby participating in complement reaction and the pathogenesis of some immune diseases. Non-c