利培酮治疗首发精神分裂症跟传统药物换用资料精.pdfVIP

安 徽 医 药 　A nhui Medical and Pharm aceutical Journal 　2002 Mar ;6 ( 1) ·31 · 利培酮治疗首发精神分裂症和传统药物换用 利培酮治疗的临床比较分析 钱建明 (安徽省安庆市精神病医院 ,安庆 　246003) 摘要 　目的 　探索利培酮治疗首发精神分裂症和传统药物换用利培酮治疗精神分裂症的临床疗效比较分析。方法 　对符合精 神分裂症诊断标准 CCMD2R ,且 BPRS 总分 ≥18 分 ,服用利培酮满 12 wk 的精神分裂症患者 ,按既往采用其他抗精神病药物 的连续治疗时间不超过 8 wk ,给予利培酮治疗者共 41 例为首发组以及按正服用其他抗精神病药物后转换利培酮治疗者共 30 例为换用组 ,分别研究组内和两组间在治疗前后 BPRS 总分的减分率情况来评定临床疗效。结果 　利培酮治疗精神分裂症疗 效显著 ,首发组治疗精神分裂症的有效率 976 % ,显效率 854 % ;换用组的有效率 900 % ,显效率 733 % 。结论 　首发组治疗 精神分裂症的疗效优于换用组。 关键词 　利培酮 ;精神分裂症 ; 首发 ; 换用 ;疗效 Comparison of thera peutic effect bet ween risperidone in the treatment patients with f irstoutset schizophrenia and exchange conventional drugs for risperidone in the treatment patients with schizophrenia Q IAN JianMing ( A n qing Mental Hospital 　246003) ABSTRACT 　AIM 　To comparison of therapeutic effect between risperidone in the treatment patients with firstoutset schizophrenia and exchange conventional drugs for risperidone in the treatment patients with schizophrenia. METHOD 　Seventyone subjects with diagnosis of schizophrenia according to CCMD2R and BPRS ≥18 were treated. 41 patients with firstoutset schizophrenia were given risperidone (firstoutset group ) . 30 patients with schizophrenia completed treatment risperidone instead of conventional drugs ( ex change group) . After treatment 12 weeks , we can compare therapeutic efect in every group and between two groups with BPRS and CGI. RESUIT 　Risperidone in the treatment patients with schizophrenia was effective. The effective rate of firstoutset group and ex change group was 97 6 % and 900 % respectively , the marked effe