中国细胞生物学学报.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2018, 40(12): 2077–2082 DOI: 10.11844/cjcb.2018.12.0218 LIMK1/Cofilin信号通路与阿尔茨海默病 林丹枫 赵东岳* (福建省发育与神经生物学重点实验室, 福建师范大学生命科学学院, 福州 350108) 摘要 异常的肌动蛋白与切丝蛋白棒状小体(Cofilin-rods)是除了Aβ噬斑及Tau神经纤维缠结 ’ β 外, 阿尔茨海默病(Alzheimer s disease, AD)的另一个显著病理特征。目前, 在基于A 噬斑进行的药 物开发尚未成功的情况下, Rac1/PAK/LIMK1/Cofilin的研究引起人们广泛的关注。因此, 研究神经 切丝蛋白(Cofilin)通路与微丝骨架(F-actin)动态周转的调控关系, 可进一步揭示AD 的病理机制及发 现新的药物靶点。 关键词 阿尔茨海默病; LIMK1/Cofilin信号通路; 切丝蛋白棒状小体 ʼ Progress of LIMK1/Cofilin Signal Pathway in Alzheimer s Disease 报 Lin Danfeng, Zhao Dongyue* 学 (Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China) 学 Abstract Abnormal Cofilin-rods (hirano bodies) are the prominent pathological features in Alzheimer’s 物 disease brains besides amyloid plaques and Tau neurofilamentous tangles. Based on that the drugs targeting β-amyloid protein were unsuccessfully designed, the involvement of Rac1/PAK/LIMK1/Cofilin signaling pathway 生 in AD pathogenesis has become a “hot” research spot in recent years. Therefore, the regulated relationship of between the Rac1/PAK/LIMK1/Cofilin pathway and F-actin dynamics can further to reveal the pathogenesis of AD 胞 and discover the drug targets against AD. Keywords Alzheimerʼs disease; LIMK1/Cofilin si