血液系统白细胞 髓系.pptx

白细胞（髓系）;粒细胞 granulocyte, GRAN;;髓系白细胞的生成、组成和分布;中性粒细胞生成;中性粒细胞半衰期;Scheme of maturation of neutrophil precursor cells;;10;11;杆状核粒细胞和分叶核粒细胞 band neutrophil and segmented neutrophil ;嗜酸性早幼粒细胞;14;15;16;17;骨髓中性粒细胞动力学;白细胞的功能;Jan Herter, and Alexander Zarbock J Immunol 2013;190:4451-4457;;2. 颗粒;3.非氧杀菌和氧化杀菌;嗜酸性粒细胞的功能 1. 黏附和趋化 2. 颗粒蛋白 3. 杀伤细菌和寄生虫 4. 限制I型超敏反应 ;单核巨噬细胞;overview of differentiation of monocytic cells in the adult;29;30;单核细胞的功能;Phagocytosis. A.?Fc receptor-mediated phagocytosis. B. CR3-mediated phagocytosis.;Heterogeneity of monocytes in blood and the contribution of different subsets to resident and inflammatory macrophages and dendritic cells (DCs) in tissues.;白细胞和或中性粒细胞减少定义;白细胞减少的原因和病理生理机制-1;白细胞减少的原因和病理生理机制-2;白细胞减少的原因和病理生理机制-3;白细胞减少的病因-1;白细胞减少的病因-2;白细胞减少的病因-3;粒细胞缺乏临床表现-1;粒细胞缺乏临床表现-2;白细胞和或中性粒细胞增多定义;白细胞增多的原因和病理生理机制-1;白细胞增多的原因和病理生理机制-2;粒细胞增多的病因-1;粒细胞增多的病因-2;粒细胞增多的病因-3;粒细胞增多的病因-4;髓系肿瘤病种; 白血病 Leukemia;John Hughes Bennett (1812-1875);Edinburgh Royal Infirmary in the mid-nineteenth century ; Rudolf Virchow (1821-1902）;流行病学 epidemiology;病因和发病机制etiology and pathogenesis;Leukemia;The Biology of Cancer (Garland Science 2007);病因和发病机制;白血病的发生;急性白血病FAB分类classification;;急性髓细胞白血病分类; M4 急性粒-单细胞性白血病 M4EO 急性粒-单细胞性白血病伴嗜酸粒细胞增多 (Acute myelomonocytic leukemia with eosinophilosis) M5 急性单核细胞性白血病 (Acute monocytic leukemia) M6 红白血病 (Acute erythroleukemia) M7 急性巨核细胞性白血病 (Acute megakaryocytic leukemia);ANLL-M1;;ANLL-M2b;ANLL-M3a;ANLL-M3b;ANLL-M4;ANLL-M4EO;ANLL-M5a;ANLL-M5b;ANLL-M6;AML-M7;ANLL-M7;/. ../wcd/myeloid1.cfm ;急性白血病MICM分型;临床表现Clinical manifestations;;;;治疗原则Therapeutic principle;急性早幼粒细胞白血病 Acute promyelocytic leukemia (AML M3);;;Differentiation agents proposed as cancer therapy;All-trans-retinol;;;As2O3 ;How does ATRA induce remission? How does PML-RARa induce APL?;;慢性粒细胞性白血病Chronic myelogenous leukemia;慢性粒细胞性白血病;慢性粒细胞性白血病;Detail from Nowell and Hungerfords paper in 1960 identifying the Philadelphia chromosome. ;Cytogeneti