非小细胞肺癌循环肿瘤细胞检测进展·综述-中国肿瘤临床.PDFVIP

862 中国肿瘤临床2013年第40卷第14期 Chin J Clin Oncol 2013,Vol.40,No.14 · · 综 述 非小细胞肺癌循环肿瘤细胞检测进展* ① ② 陈 鹏 综述 李 雷 审校 摘要 肺癌是世界范围内发病率最高的恶性肿瘤，约有18%的癌症相关死亡与肺癌有关。循环肿瘤细胞（CTCs）的出现可 看做是肿瘤细胞播散入血的直接体现，而这正是导致非小细胞肺癌患者预后较差的最重要因素之一。检测外周血中循环肿瘤细 胞有望成为诊断肺癌的辅助方法，使肺癌患者得到最佳的个体化治疗。研究者们已尝试多种不同的方法从外周血中分离CTCs。 虽然有关CTCs检测的研究众多，但不同检测方法的敏感度、特异性及重复性限制了其临床意义，本文就现有的各项技术进行综 述。 关键词 循环肿瘤细胞 非小细胞肺癌 检测技术 化疗 doi:10.3969/j.issn.1000-8179.2013.14.013 Advances in detection of circulating tumor cells in non-small cell lung cancer 1 2 Peng CHEN , Lei LI Correspondence to: Lei LI; E-mail: chenpengdoc@ 1Center for Lung Cancer Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China 2Chinese Academy of Science Institute of Physics and Chemistry, Beijing 100000, China This work was supported by the general projects of National Natural Science Foundation of China (No. Abstract Lung cancer is the most common cancer worldwide, accounting for approximately 18% of all cancer-related deaths. Circulating tumor cells (CTCs) have the capacity to spread into the blood stream. This capacity of CTCs is one of the most critical fac- tors for unfavorable clinical outcome of patients with NSCLC. Detection of CTCs using a simple blood test may assist in early detec- tion of lung cancer. Researchers have attempted to isolate CTCs from peripheral blood using various techniques. Although reports on CTC detection are abundant, methodological aspects concerning sensitivity, specificity, and reproducibility have prevented a clear ap- praisal of the clinical impact. This paper gives a brief description of each CTC detection method. Keywords: circulating tumor cells, non-small cell lung cancer, detection, chemotherapy 肺癌是世界范围内发病率及死亡率