地氯雷他定辅助阿奇霉素治疗小儿支原体肺炎疗效观察.docxVIP

地氯雷他定辅助阿奇霉素治疗小儿支原体肺炎疗效观察 蒋华治計 刘铁明2杨茜1 (1中山市人民医院药学部 广东中山528403; 2 中山市人民医院儿科广东中山528403) 【中图分类号】R978.1【文献标识码】A【文章编号】1672-5085 (2012) 28-0152-02 【摘要】目的观察阿奇霉素联合地氯雷他定治疗小儿支原体肺炎的临床疗效。 方法108例患儿随机分为对照组和治疗组，每组54例。两组均给予化痰、止咳、 平喘、退热等常规治疗，同时对照组采用阿奇霉素(辉瑞制药有限公司)口服治 疗,治疗组采用阿奇霉素(辉瑞制药有限公司)联合地氯雷他定干混悬剂(海南 普利制药有限公司)口服治疗。观察两组病情恢复时间和疗效。结果 治疗组疗 效显著好于对照组,Plt;0.05；治疗组病情恢复时间明显快于对照组,Plt;0.05o 结论阿奇霉素联合应用地氯雷他定干混悬剂治疗小儿支原体肺炎可以缩短患 儿的治疗周期，有效提高治疗效果，减少不良反应，减轻病人的经济负担，值得在 临床推广。 【关键词】地氯雷他定阿奇霉素小儿支原体肺炎 [Abstract ]Objective To observe the curative effect of desloratadine with azithromycin on treatment of children with mycoplasma pneumonia.Methods： 108 cases of mycoplasma pneumonia children were randomly divided into control groups and treatment groups of 54 cases each.Both groups were given regular treatment for reducing phlegm, relieving coughs, soothing asthma and treating fevers.At the same time oral dosage of azithromycin(Pfizer Pharmaceuticals Limited) was added in the control group while desloratadine(Hainan Poly Pharm.Co.Ltd.) with azithromycin(Pfizer Pharmaceuticals Limited) was used orally in the treatment group.Time for recovery and the effectiveness of the treatments were observed.Result: Patients in the treatment group have both better treatment result(P lt; 0.05 ) and faster recovery time (P lt; 0.05) than patients in the control group.Conclusion: Desloratadine with azithromycin for children with mycoplasma pneumonia, which reduces time for recovery and improves treatment result with less side effect and lighter economic burden on patients, is to be put in wider use in clinical practice. [Key words] desloratadine Azithromycin children with mycoplasma pn eum onia 支原体肺炎（mycoplasmal pneumonia）是由支原体（mycoplasmazMP） 感染引起的、基本病呈间质性肺炎及毛细支气管炎样改变，临床表现为顽固性剧 烈咳嗽的肺部炎症。MP是儿童吋期肺炎和其它呼吸道感染的重要病原之一。近 些年来研究表明，小儿支原体肺炎已占小儿肺炎总例数的10%?30%,且发病 率还呈逐渐上升和局部流行的趋势[1]。本研究通过采用阿奇霉素联合应用地氯 雷他定治疗小儿支原体肺炎，取得了较好的疗效，现将结果报告如下： 1资料与方法 一般资料:选择我院2011年3月至2012年3月门诊患儿共108例, 男 58 例，女 50 例gt;l 且 lt; 3 岁 8 例,gt;3 且 lt; 6 岁 68 例，gt； 6 且lt; 12 岁32