课件：Fever病理生理学英文.ppt

THANK YOU SUCCESS * * 可编辑 * degree Centigrade * Salmonella typhimurium:鼠伤寒沙门(氏)菌 * Brucella 布鲁氏菌 40 39 38 37 36 remittent fever C Sepsis, severe tuberculosis (TB), rheumatic fever 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 day 弛张热 40 39 38 37 36 intermittent fever C malaria 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 day 间歇热 40 39 38 37 36 undulant fever C Brucella disease 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 day 波状热 40 39 38 37 36 irregular fever TB, rheumatic fever C 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 day 不规则热 (1) category of EP Part 2 Etiology Pathogenesis 2. endogenous pyrogen (EP) IL-1 monocyte / macrophage / endotheliocyte IL-6 monocyte / fibrocyte / endotheliocyte TNF macrophage / lymphocyte? IFN WBC / monocyte MIP-1 macrophage (2) The characters of EP Part 2 Etiology Pathogenesis a. The component is protein b. Light molecular weight?, easy to cross the BBB. c. Poor stability, Thermolabile. d. species specificity. 2. endogenous pyrogen (EP) (2) The characters of EP Part 2 Etiology Pathogenesis e. latent period about 15 min. f. Pyrogenic dose is 30~50ng. g. No toleration. h. The responsive site is POAH. i. Function: up-regulate the set point of thermostat center. 2. endogenous pyrogen (EP) THANK YOU SUCCESS * * 可编辑 Comparison between pyrogenic activator (ET) and endogenous pyrogens ET EP IL-1 TNF IFN MIP-1 origin G-, B M?, tumor C M ?, LC WBC,MN MN components LPS glycopro. Pro. glycopro. HCP Molecule wt 5~9000kd 12~18 17~25 15~17 ? Heat resistant + - - +-