中药药对及其有效成分抗脑缺血损伤的研究进展.PDFVIP

·3162 · 中草药 Chinese Traditional and Herbal Drugs 第 49 卷 第 13 期 2018 年 7 月 中药药对及其有效成分抗脑缺血损伤的研究进展 * 毛冬雪，祝美珍 ，齐景馨，曾宪晶，俞 睿 广西中医药大学，广西 南宁 530001 摘 要：药对的配伍规律及其作用机制的深入研究对临床遣药组方及提高疗效具有重要的科学内涵。近年来，许多脑缺血损 伤的防治研究发现，通过中药药对的合理运用，实现中药复方的优化组合，可多靶点、多层面作用于缺血脑组织的神经血管 单元，多途径调控相关信号通道，明显减轻缺血半暗带脑组织的损伤及脑缺血损伤引起的炎症级联反应和再灌注损伤，及时 恢复脑部血流并有效保护神经元，取得“复流”与“脑保护”相似的作用，进一步促进了神经功能的修复。 关键词：中药药对；有效成分；脑缺血损伤；神经功能；配伍规律 中图分类号：R285 文献标志码：A 文章编号：0253 - 2670(2018)13 - 3162 - 04 DOI: 10.7501/j.issn.0253-2670.2018.13.031 Research progress on Chinese materia medica pairs and their active components against cerebral ischemia MAO Dong-xue, ZHU Mei-zhen, QI Jing-xin, ZENG Xian-jing, YU Rui Guangxi University of Chinese Medicine, Nanning 530001, China Abstract: The in-depth study on the law of drug pair compatibility and its mechanism has important scientific connotation for the clinical prescriptions and the improvement of curative effect. In recent years, many prevention and treatment of cerebral ischemic injury found that the rational use of Chinese materia medica pairs by optimizing the combination of Chinese medicine compound played a multi-target, multi-level role in the ischemic brain tissue of the neurovascular units, multi-channel regulation of the relevant signal pathways, which can significantly reduce the damage of ischemic penumbra brain tissue, relieve the inflammatory cascade and reperfusion injury caused by cerebral ischemia injury, promptly restore the blood flow in the brain and effectively protect the neurons, achieve “re-flow” and “brain protect” similar effects, and further promote the repair of nerve function. Key words: Chinese materia medica pairs; active ingredient; cerebral ischemic injury; nerve function; compatibility rule 药对作为中药配伍的基本形式，是在中医药基 血损伤引起的炎症级联反应和再灌注损伤，达到了 本理论的指导下，以药物功效和治法为依据用药的