标题依托咪酯两种诱导剂量与标准诱导剂量的比较研究摘要翻译.PDFVIP

标题：依托咪酯两种诱导剂量与标准诱导剂量的比较研究 摘要翻译：何幼芹 背景及目的：在寻找理想的静脉诱导药物方面，依托咪酯仍是最前沿的药物， 因为它在不影响诱导终点的情况下提供血流动力学稳定性。据相关研究报道， 减慢丙泊酚的输注速度可以减少诱导时所需的剂量。尽管依托咪酯在诱导时具 有良好的血流动力学稳定性，但它的皮质醇抑制功能仍是人们关注的焦点。本 研究旨在探讨减慢依托咪酯的输注速率是否会减少诱导时所需的剂量，同时评 估是否减少了不良反应。 方法：将96 例患者按依托咪酯剂量随机分为3 组。给予依托咪酯，直至睫毛反 射消失和达到熵50 。记录依托咪酯的总用量、眼睫毛反射消失所需时间和达到 熵50 的时间。在不同的时间间隔测定皮质醇水平。 结果：研究结果显示，减慢依托咪酯输注速度可减少其用于诱导时的剂量，但 延长麻醉诱导时间。3 组均在诱导后6 小时内皮质醇水平降低，但仍在正常范 围内，24 h 达诱导前水平。 结论：注射速度越慢，诱导所用依托咪酯的剂量越小，但达到诱导终点所需的 时间越长。以较低的速率注入依托咪酯可避免肌阵挛的发生。 原始文献来源： Prakash M V S Satya,Gnanasekar Rajiv,Sakthirajan Panneerselvam et al. A comparative study of two infusion doses of etomidate for induction vs standard induction dose of etomidate.[J] .Eur. J. Clin. Pharmacol., 2019, undefined: undefined. 附图： Title: A comparative study of two infusion doses of etomidate for induction vs standard induction dose of etomidate [Abstract] Background In the search for the ideal intravenous induction drug, etomidate is in the forefront as it provides haemodynamic stability without compromising on the end point of induction. It has been established that slowing the rate of infusion of propofol decreases the dose required for induction. Even though etomidate provides good haemodynamic stability while inducing, there is concern about its cortisol suppressive function. This study has been designed, with entropy guidance, to establish whether induction by slowing the rate of infusion of etomidate will reduce the dose required for induction and simultaneously assess whether adverse effects are reduced. Methods Ninety-six patients were randomly allocated into three groups based on etomidate dose. Etomidate dose was given till both loss of eyelash reflex and entropy50 was achieved. Total dose of etomidate consumed, time taken for loss of eye lash reflex and time to reach entropy50 were recorded. Cortisol levels were measured at different intervals. Results We observed that slowing the rate of