胎儿透明隔腔消失的超声与MRI对比分析-第三军医大学学报.doc

胎儿透明隔腔消失的超声与MRI对比分析 焦北鱼1,4，王锡明2，王光彬3，聂 佩1 （250021济南，山东大学医学院1,山东省医学影像研究所CT研究室2，山东省医学影像研究所MR研究室3，266012山东 青岛,青岛市妇女儿童医院特检科4） [摘要] 目的 探讨胎儿透明隔腔消失的影像诊断意义。方法 回顾性分析自2009年1月1日至2011年6月31日在青岛市妇女儿童医院系统产前超声检查中检出的透明隔腔消失的67例病例，以前脑无裂、胼胝体发育不良及孤立性透明隔腔消失将病例分为三组，分析其超声及MRI特点，比较胎儿期透明隔腔消失病例影像学诊断方法的准确情况。结果 67例超声筛查胎儿透明隔腔消失，其中胼胝体发育不良31例(46.3%)，前脑无裂畸形22例(32.8%)， 孤立性透明隔腔消失病例14例（20.9%），同时行产前MRI检查并随访资料完整的40例病例计入统计，收集其病例的引产后解剖病理结果或引产后标本影像学检查结果。随访至足月分娩仅3例，均为孤立性透明隔腔消失病例，其中最大者随访至2岁1个月，神经学检查均未见明显先天性结构异常。对照样本的产前MRI、超声检查与（引）产后病例诊断或标本影像学检查的诊断符合率。其中产前MRI诊断符合率均为100%，而产前超声的诊断符合率分别为胼胝体发育不良100%，前脑无裂畸形93.3%，孤立性透明隔腔消失75%。进行生前MRI、引产后解剖或影像学检查证实。结论 超声筛查中出现的胎儿透明隔腔消失，应结合孕周连续观察，并注意其与其他中枢神经系统畸形的相关性，对孤立存在的透明隔腔消失应慎重做出畸形诊断，MRI在透明隔腔的显示效果及诊断准确率较超声更精确。 [关键词] MRI；产前超声；透明隔腔 [中图法分类号] [文献标志码] A Prenatal ultrasonography and MRI analysis of absence of cavum septum pellucidum Jiao Beiyu1,3,Wang Ximing2, Wang Guangbin2,Nie Pei1(1medical college of Shandong university, 2Shandong medical imaging research insititute,250021,china， 3WomenChildren hospital of Qingdao ,Shandong ,266012,china) [Abstract] Objective To analyse the value of the MRI and ultrasonography（US）in the prenatal diagnosis of absence of cavum septum pellucidum（CSP）. Methods Fetal absence of CSP was suspected in 67 pregnant women by prenatal US from January 2009 to June 2011 in Qingdao women children hospital. Prenatal systemic ultrasonography was performed,analysing the findings of prenatal US and MR images and their following-ups，comparing the diagnosis accuracy of these two imaging studies . Results 31(46.3%) fetuses were Agenesis of Corpus callosum(ACC) in 67 pregnant women. 22（2.8%） fetuses were holoprosencephal, and 14（20.9%） fetuses were suspected to be isolated absence of CSP.3fetuses　were term　born,　and the oldest one was 2.1 years old up to now．all these cases seem to be normal. We compared the coincidence ratio between prenatal MRI, ultrasound examination and postpartum/ odinopoeia cases imaging/specime