肺癌低氧微环境与化疗耐药相关性研究进展.PDF

265 中国肺癌杂志2 0 1 4 年 3 月第 1 7卷第 3 期 Chin J Lung Cancer, March 2014, Vol.17, No.3 · · DOI: 10.3779/j.issn.1009-3419.2014.03.14 · 综 述 · 肺癌低氧微环境与化疗耐药相关性研究进展 郭洋 吴密璐 赵君慧 李瑜英 【 】肺癌是我国近年来发病率最高的恶性肿瘤之一，肿瘤低氧首先在肺癌中被发现，低氧与肿瘤细胞的 摘要 耐药、凋亡、迁徙、血管生成等有密切联系。化疗耐药是肺癌治疗失败、病情进展的重要原因之一，近年来相关研 究较多，现对肺癌低氧微环境以及其诱导化疗耐药作用机制的研究进展进行综述。 【关键词 】低氧；肺肿瘤；化疗；耐药 Advances in Hypoxia Microenvironment and Chemotherapy-resistant of Lung Cancer 1 2 2 2 Yang GUO , Milu WU , Junhui ZHAO , Yuying LI 1Qinghai University, Xining 810001, China; 2Department of Oncology, Affilitated Hospital of Qinghai University, Xining 810001, China Corresponding author: Milu WU, E-mail: 452694116@ Abstract Lung cancer is one of the malignant tumors with highest incidence recently in our country. Tumor 【 】 hypoxia phenomenon was first discovered in lung cancer. It plays important roles in tumor cell drug-resistance, apoptosis, inva- sion and metastasis, angiogenesis. Chemotherapy-resistant is one of the core reasons of treatment failure and disease progress, and many works on the study of chemotherapy-resistant have been done. This article reviewed the research progress of those mechanisms by which lung cancer hypoxia microenvironment could induce chemotherapy-resistance. Key words Hypoxia; Lung neoplasms; Chemotherapy; Drug-resistance 【 】