明胶掺锶β磷酸三钙硫酸钙复合多孔支架的制备与性能研究.docxVIP

明胶/掺總B -磷酸三钙/硫酸钙复合多 孔支架的制备与性能研究 秦晓素黄洁雷云杨泽斌陈庆华颜廷亭 昆明理工大学材料科学与工程学院 摘要： 以掺總B -磷酸三钙/硫酸钙为原料，利用搅拌喷雾干燥法制备出掺總B-磷酸 三钙/硫酸钙复合小球，再将明胶与制备的复合小球复合，制备出明胶/掺總 B-磷酸三钙/硫酸钙复合生物支架。通过X射线衍射仪、扫播电镜、红外光谱等 分析复合多孔支架的成分、形貌以及结构特征，并研究复合牛物支架的降解性、 孔隙率、力学性能和细胞毒性等。结果表明：该复合多孔生物支架具有不规则的 孔洞结构，孔径在0.5?1 nrniZ间，且平均孔隙率达到(63±1?77) %,基本能 满足骨组织工程支架对孔隙率的要求;复合多孔支架具有良好的抗压强度，其平 均抗压强度在6.3±0. 05 MPa左右;该复合多孔支架无细胞毒性，具有较好的降 解速率，因此该支架在骨组织修复方面具有良好的应用前景。 关键词： 明胶;掺總B-磷酸三钙;硫酸钙;复合小球;多孔支架; 作者简介：秦晓素:女，1991年生，硕士，研究方向为生物骨科材料 E-ma订：769860685@qq. com 作者简介：颜廷亭:通讯作者，男，1983年生，博士，副教授，硕士生导师，主 要研究方向为生物医用材料的研究Ena订：itty@foxma订.com 基金：国家自然科学基金 Study on Fabrica tion and Proper ties of Porous gelatin/Strontium-doped P -Tricalcium Phosphate/Calcium Sulfate Scaffolds QIN Xiaosu HUANG Jie Lei Yun YANG Zebin CHEN Qinghua YAN Tingting Faculty of Materials Science and Engineering, Kunming University of Science and Technology; Abstract： The present work fabricated the calcium sulfatc/strontium-dopcd B -tricalcium phosphate composite spherical pellets through the stirring spray drying method and using the calcium sulfate/strontium-doped B -TCP as raw material. Subsequently the composite spherical pellets were combined with gelatin, to get porous gelatin/calcium sulfate/strontium-dopcd B-tricalcium phosphate scaffolds. We employed X-ray diffraction (XRD) , scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR) , etc. to examine the products chemical composition, morphology and microstructure, and also investigated the degradability, porosity, mechanical properties and cytotoxicity. The resuIts reveal that the compositc porous scaffolds have an irregular pore structure with pore size ranging from 0. 5 to 1. 0 mm and the porosity of about (63± 1. 77) %, which could meet the requirements of scaffold for bone tissue engineering. Besides, the favorable compressive strength (average value (6. 3±0. 05) MPa) of the resultant scaffolds were observed. The cytotoxicity test showed that, the composite scaffolds exhibit n