ReviewofPolyploidGiantCancerCells多倍体肿瘤巨细胞研究进展.PDFVIP

World Journal of Cancer Research 世界肿瘤研究, 2019, 9(1), 45-59 Published Online January 2019 in Hans. /journal/wjcr /10.12677/wjcr.2019.91008 Review of Polyploid Giant Cancer Cells Juan Yu, Renya Zhang, Wei Wang* Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Shandong rd th th Received: Dec. 23 , 2018; accepted: Jan. 9 , 2019; published: Jan. 16 , 2019 Abstract Polyploid giant cancer cells (PGCCs) is a special subgroup of cancer cells, often containing a single giant cell nucleus or multiple nuclei, and the nucleus is usually irregular. Compared with normal diploid cancer cells, PGCCs was different in cell cycle, proliferation pattern, differentiation ability, morphology, size, chromosomal abnormalities, tumorigenicity, radiotherapy and chemotherapy. PGCCs has not been valued in the past, and it is generally considered that PGCCs is at the edge of mitosis and the edge of apoptosis, which is not divided, so it is considered to be unviable. However, recent studies have found that PGCCs is not only viable but also has embryonic stem cell like cha- racteristics. It produces multiple differentiations through asymmetric division of the progeny cells, and plays an important role in chemoresistance, proliferation, epithelial transformation and inva- sion and metastasis. In this paper, the research progress of PGCCs in recent years is reviewed, providing a new direction and method for clinical treatment. Keywords Polyploid Giant Cancer Cells, Multidirectional Differentiation, Chemoresistance, Epithelial Mesenchymal Transition, Invasion and Metastasis 多倍体肿瘤巨细胞研究进展 于 娟，张仁亚，王 卫* 济宁医学院附属医院病理科，山东 济宁 收稿日期：2018年12月23 日；录用日期：2019年1月9 日；发布日期：2019年1月16 日