TNF-α基因-308GA多态性与中国人群强直性脊柱炎相关性的强直性脊柱.PDFVIP

Review Articles Chin J Evid-based Med 2016, 16(8): 906-912 TTNF-NF-α--308G/A308G/A MMetaeta 1,2 2 1 2 2* 1. 4300002. 430000 Meta αTNF-α-308G/A AS PubMedEMbaseCNKICBMWanFang Data VIP TNF-α-308G/A AS - 2015 12 2 Stata12.0 Meta 11 - 1 154 AS 1 458 Meta TNG-α-308G/A AS A vs. G OR=0.96 95%CI0.631.47P=0.86 AA vs. AG OR=0.9795%CI0.511.84P=0.93 AA vs. GG OR=0.9295%CI0.32 2.61P=0.87 AA+AG vs. GG OR=1.0495%CI0.601.80P=0.89 AA vs. AG+GG OR=1.0395%CI0.581.82 P=0.92 TNF-α-308G/A AS Meta Correlation between Polymorphism in Tumor Necrosis Factor α Gene -308 G/A and Ankylosing Spondylitis in Chinese Population: A Meta-analysis 1,2 2 1 2 2* RUAN Xiao-lan , LI Sheng , AO Xu-bin , HUANG Jing-yu , WENG Hong 1. Department of Hematology, Renmin Hospital of Wuhan University, Wuhan 430000, China; 2. Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430000, China Abstract Objective To evaluate the relationship between tumor necrosis factor-α (TNF-α) gene promoter -308 G/A polymorphism and ankylosing spondylitis (AS) in Chinese population by meta-analysis. Methods The case- control studies about the correlation between TNF-α gene polymorphism and AS in Chinese population were retrieved from PubMed, EMbase, CNKI, CBM, WanFang Data and VIP database by two researchers. The retrieval time was from their establishment to December, 2015. After the paper screening, data extraction, and assessment of bias risk, the meta- analysis was conducted by Stata 12.0 software. Results A total of 11 case-control studies involving 1 154 AS patients and 1 458 controls were included. The results of meta-analysis showed that, for Chinese population, there was no significant association between TNF-α -308 G/A polymorphism and AS susceptibility (A vs. G: OR=0.96, 95%CI 0.63 to