XRCC1单核苷酸多态性与鼻咽癌铂类化疗敏感度的相关性-肿瘤防治研究.PDFVIP

2015 42 7  Cancer Res Prev Treat,2015,Vol.42,No.7 681 肿瘤防治研究 年第 卷第 期 · · doi:10.3971/j.issn.1000-8578.2015.07.009 · · 临床研究 XRCC1单核苷酸多态性与鼻咽癌铂类化疗 敏感度的相关性 * 刘龙静，李桂生，陈海辉 Correlation of DNA Repair Gene XRCC1 Single Nucleotide Polymorphism with Sensitivity of Nasopharyngeal Carcinoma Patients to Platinum Chemotherapy * LIU Longjing, LI Guisheng, CHEN Haihui Department of Medical Oncology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China (*: Contributed Equally as First Author) Corresponding Author: LI Guisheng, E-mail:163.com Abstract: Objective To explore the correlation of codon194 and codon399 single nucleotide polymorphisms (SNP) of DNA repair gene X-ray repair cross-complementing gene 1(XRCC1) with the sensitivity to platinum chemotherapy in nasopharyngeal carcinoma(NPC)patients. Methods The biopsy specimens were obtained from NPC patients diagnosed by nasopharyngeal endoscopy in The Fourth Affiliated Hospital of Guangxi Medical University from September 1 2012 to December 31 2013. XRCC1 SNP at codon194 and codon399 in NPC patients were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After 2 periods of PF(cisplatin+5-fluorouracil) induction chemotherapy, MRI was taken to assess the efficacy according to RECIST 1.1 standard, evaluate the relationship between SNP and the sensitivity of chemotherapy in nasopharyngeal cancer patients. Results The patients with XRCC1 codon399 Gln/Gln polymorphisms were 3.500 times as sensitive to the chemotherapy as the patients with