YAP与肿瘤干细胞相关性研究进展·综述-中国肿瘤临床.PDFVIP

728 中国肿瘤临床2015年第42卷第14期 ChinJClinOncol2015.Vol.42.No.14 综 述 · · YAP与肿瘤干细胞相关性研究进展* ① ① ② 李海欣 何娜 综述 郑红 审校 摘要 YAP是一种多功能蛋白，可以与不同的转录因子相互作用激活基因的表达。YAP作为活化Hippo途径的关键转录调 节蛋白在调节器官大小、细胞自我更新、干细胞和组织特异性祖细胞扩增等方面发挥重要作用，在Hippo途径中MST1/2激酶和其 结合蛋白SAV共同磷酸化激酶LATS1/2，激活的LATS1/2磷酸化YAP从而抑制YAP蛋白的活性。近年来，大量的研究已经在胚 胎干细胞、神经干细胞、造血干细胞中发现YAP的高表达能够维持干细胞干性并且已经成为维持干性的标志物，随后的研究发现 信号通路可能与肿瘤干细胞（CSC）分化密切相关。本文主要讨论YAP在维持干细胞及肿瘤干细胞干性方面的作用。 关键词 YAP 干细胞 肿瘤干细胞 干性 doi:10.3969/j.issn.1000-8179 Advances in YAP on stemness maintenance of cancer stem cell Properties 1 1 2 Haixin LI , Na HE , Hong ZHENG Correspondence to: Hong ZHENG; E-mail: zhengh64@ 1Department of Cancer Biobank, 2Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China This work was supported by the National Innovation Team Development Planning (No. IRT_ 14R40) and Hospital-funded Project of Tianjin Medical University Cancer Institute and Hospital (No. 1418) Abstract Yes-associated protein (YAP) is a multifunctional protein that can interact with different transcription factors to acti- vate gene expression. YAP, as the key transcription protein of Hippo pathway, has made important contribution to the control of the or- gan size, stem cell biology, and tissue-specific stem cell self-renewal. In the Hippo pathway, MST 1/2 kinases, together with the adaptor protein SAV, phosphorylate LATS 1/2 kinases. YAP is phosphorylated and inhibited by the activated LATS 1/2, a key component of the Hippo tumor suppressor pathway. In recent years, numerous studies have shown that the high expression of YAP in the embryonic stem cells, neural stem cells,