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HIGHLIGHTS OF PRESCRIBING INFORMATION Treatment is repeated daily for five days. This five-day treatment course may
These highlights do not include all the information needed to use Fusilev be repeated at 4 week (28-day) intervals, for 2 courses and then repeated at 4
safely and effectively. See full prescribing information for Fusilev. to 5 week (28 to 35 day) intervals provided that the patient has completely
Fusilev® (levoleucovorin) FOR INJECTION, POWDER, recovered from the toxic effects of the prior treatment course.
LYOPHILIZED, FOR SOLUTION for INTRAVENOUS use
® In subsequent treatment courses, the dosage of 5-FU should be adjusted based
Fusilev (levoleucovorin) INJECTION, SOLUTION for INTRAVENOUS
on patient tolerance of the prior treatment course. The daily dosage of 5-FU
use
should be reduced by 20% for patients who experienced moderate
Initial U.S. Approval: 1952 (d,l-leucovorin), 2008 (levoleucovorin)
hematologic or gastrointestinal toxicity in the prior treatment course, and by
RECENT MAJOR CHANGES
30% for patients who experienced severe toxicity. For patients who
Indications and Usage (1) 04/2011 experienced no toxicity in the prior treatment course, 5-FU dosage may be
Dosage and Admi
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