Choose of oral antihyperglucemic agents Older patients:short term SU Obesity or hyperinsulinism patients:biguanides or acarbose 2hPG :α-glucosidase Concentration of plasma glucose:270 ? 300mg/dl. the symptoms of hypertension are evident .Insulin therapy is available Impaired liver and kidney function:avoid using OHA Lean 、 fasting and after-excitation insulin all :insulin Drug-Combined therapy Reasonable diet and poor plasma glucose control by monotherapy SU 、biguanides 、TZD and α- glucosidase inhibitors all can be used in combination with each other Small dosage combined with of
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