Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice智能手机控制的光基因工程细胞能够在糖尿病小鼠中实现半自动的葡萄糖稳态.pdfVIP

S C I E N C E T R A N S L A T I O N A L M E D I C I N E | R E S E A R C H A R T I C L E C E L L E N G I N E E R I N G 2017 © The Authors, some rights reserved; Smartphone-controlled optogenetically engineered exclusive licensee American Association cells enable semiautomatic glucose homeostasis in for the Advancement of Science. diabetic mice Jiawei Shao,1 Shuai Xue,1 Guiling Yu,1 Yuanhuan Yu,1 Xueping Yang,1 Yu Bai,2 Sucheng Zhu,1 Linfeng Yang,1 Jianli Yin,1 Yidan Wang,1 Shuyong Liao,1 Sanwei Guo,3 Mingqi Xie,1,4 1,4 1 Martin Fussenegger, Haifeng Ye * With the increasingly dominant role of smartphones in our lives, mobile health care systems integrating ad- vanced point-of-care technologies to manage chronic diseases are gaining attention. Using a multidisciplinary design principle coupling electrical engineering, software development, and synthetic biology, we have engi- neered a technological infrastructure enabling the smartphone-assisted semiautomatic treatment of diabetes in mice. A custom-designed home server SmartController was programmed to process wireless signals, enabling a smartphone to regulate hormone production by optically engineer