医学遗传与胚胎发育13.pdfVIP

Chapter 14 Cancer genetics Cancer genetics 梅艳芳 沈殿霞 陈晓旭 罗京 Cancer is one of the most common and Cancer is one of the most common and severe diseases seen in clinical medicine severe diseases seen in clinical medicine Strikes more than one third of the population， Accounts for more than 20% of all deaths ， In developed countries, is responsible for more •lung (1.3 million deaths/year) •stomach (803 000 deaths) •colorectal (639 000 deaths) than 10% of the total cost of medical care. •liver (610 000 deaths) •breast (519 000 deaths). 2004 worldwide from WHO Three main forms of cancer Three main forms of cancer Hematopoietic and lymphoid malignancies Lymphoma Sacoma (Lymphoid) Leukimia (Mesenchymal tissue) (Hematopoietic) 2% 5% 3% 5% ALL Other AML melanomas 85% carcinoma (Epithelial tissue) Invasion Metastasis Esophagus carcinomas Colon carcinomas to liver What is cancer What is cancer Cancer is not a single disease but a more virulent forms of neoplasia , a disease process characterized by uncontrolled cellular proliferation leading to a mass o