穿琥宁注射液与24种药物配伍的稳定性考察.docVIP

???? 穿琥宁注射液与24种药物配伍的稳定性考察 ???? ???? 摘要　目的：研究穿琥宁注射液与临床常用24种药物 配伍的稳定性。方法：考察穿琥宁注射液与24种药物在室温下配伍后外 观、pH、微粒和紫外吸收度。结果：穿琥宁注射液与庆大霉素、丁氨卡 那霉素、环丙沙星、氧氟沙星配伍产生沉淀，与VitC、VitB6、ATP、辅酶A、胞二磷胆碱 、氨茶碱、氢化考的松、地塞米松、三氮唑核苷、阿昔洛韦、双黄连、青霉素钠、氨苄西林 钠、红霉素、头孢唑啉钠、头孢哌酮钠、头孢曲松钠、头孢呋辛钠、甲硝唑、替硝唑配伍无 显著变化。结论：穿琥宁注射液不宜与庆大霉素、丁氨卡那霉素、环丙 沙星、氧氟沙星配伍，可与其他20种药物配伍应用。关键词　穿琥宁;药物;配伍;稳定性 Study on the stability of the compatibility of kalii dehydrographolidi succinas injection with 24 drugsYin Lixin(Yin LX),Liu Xiuju(Li u XJ),Hu Yongfu(Hu YF),et al(The Second Hospital of Hebei Medica l University,Shijiazhuang 050000) ABSTRACT　OBJECTIVE ：To study the stability of the compatibility of kalii dehydrogrpholidi su ccinas injection with 24 drugs.METHODS:Under home temperature,the UV absorbance,pH and pariclle of the kalii dehydrographolidi succinas injection wi th 24 drugs was dettermined by UV,pH meter or pariclle counter for injection,and the aspect was observed too.RESULTS:The comptibility of kalii dehyd rographolidi succinas injection with gentamicin,amikacin,ciprofloxacin and oflox acin appeared precipitation,but with vitamin C,vitamin B6,adenosinetriphosphat e,coenzyme A,natrii citicolini,aminophylline,hydrocortisone,dexamethasone,ribavi rin,aciclovir,shuanghuanglian,penicillin,ampicillin,erythromycin,cefazolin,cefop erazone,ceftriaxone,cefuroxime,metronidazole and tinidazoli,no significant chang e was found in the aspect,pH,particulate and UV absorbance.CONCLUSION:Kalii dehydrographolidi succinas injection could not combine with gentamicin,a mikacin,ciprofloxacin and ofloxacin,but could combine with other 20 drugs.KEY WORDS　kalii dehydrographolidi succinas,drugs,stability,compatibilit y　　穿琥宁(Kalii Dehydrographolidi Succinas)注射液是从 中药穿心莲叶中提取的穿心莲内酯经化学半合成的广谱抗病毒新药，化学成分为脱水穿心莲 内酯琥珀酸半酯单钾盐(C28H35KO10)，临床广泛用于各种病毒性感染。 我们选用了临床上常用的24种药物与穿琥宁注射液进行配伍稳定性实验，为临床合理用药提 供依据。1　仪器与药品　　UV-260型分光光度计(日本岛津)；pHS-2型酸度计(上海雷磁仪器厂)；ZWF-4DⅡ型注射液微 粒分析仪(天津市天河医疗仪器研制中心)；5%葡萄糖注射液、生理盐水(本院自制)，配伍药 品见表1。2　方法与结果2.1　方法　　模拟临床常用浓度配制配伍液，将配伍药物用5%葡萄糖注射液(5%GS)或生理盐水(NS)