肌壁大部切除子宫重建术联合曼月乐治疗中、重度子宫腺肌病的疗效.docVIP

肌壁大部切除 子宫重建术联合曼月乐治疗 中、重度子宫腺肌病的疗效 作者:王越凤 刘高焰 陈涛 来源:《右江医学》 2015年第 02期 【摘要】 目的 观察肌壁大部切除 -子宫重建术(MURU 联合曼月乐(MIR 治疗中、重 度子宫腺肌病(ADE 的疗效。 方法 选择 2011年 5月至 2013年 5月住院治疗的有保留子宫意愿的中、重度 ADE 患者 100例作为研究对象。根据超声检测的子宫肌壁厚度及腺肌瘤的最大直径将患者分成两组,中 度组 52例,重度组 48例。两组患者均给予 MURU 联合 MIR 治疗。对比观察两组手术时间、 术中出血量,痛经评分及经量评分,治疗前后患者的血清糖类抗原 125(CA125。 结果 中度组患者手术时间显著短于重度组(P0.05。治疗后两组 CA125值均显著下降 (P0.05。两组患者术后及治疗期间无并发症发生。 结论 MURU联合 MIR 治疗中、重度 ADE 疗效显著,具有较好的安全性,值得推广。 【关键词】 肌壁大部切除;子宫重建术;曼月乐;子宫腺肌病 中图分类号:R713.4 文献标识码:A 【 Abstract 】 Objective To study the efficacy of major uterine wall resection-reconstruction of the uterus (MURU combined with mirena (MIR in the treatment of moderate and severe adenomyosis (ADE . Methods 100 cases of moderate and severe ADE―who admitted to our hospital from May, 2011 to May, 2013 and had the wish to keep their uterus―were selected as the study objects.They were divided into moderate group(52 cases and severe group(48 cases according to uterine muscle wall thickness and maximum diameter of ADE displayed by ultrasonography.Both groups were treated with MURU combined with MIR.Then, operation time, blood loss during operation, dysmenorrhea score, menstrual blood volume score, serum carbohydrate and serum carbohydrate antigen 125 (CA125 before and after treatment were observed and compared between groups. Results Operation time of the moderate group was significantly shorter than that of the severe group (P0.05 .After treatment, values of CA125 of both groups significantly decreased (P0.05 .No complications were found in both groups during and after operation. Conclusion MURU combined with MIR has obvious therapeutic effect in the treatment of moderate and severe ADE with relatively high security.Thus, it is worthy of application and popularization in clinic. 【 Key words】 major uterine wall resection; uterine reconstruction; mirena ; adenomyosis 子宫腺肌病(Adenomyosis , ADE 是一种妇科多发病,以经量多、经期长及逐渐加剧的 进行性痛经为显著症状,多认为子宫腺肌症是基底层内膜细胞增生、侵入到肌层间质的结果, 对其自身生殖健康及生活质量均产生一定影响 [1]。目前尚无根治本病的有效药物,传统的治 疗为子宫全切术。