肿瘤细胞代谢与肿瘤转移相互关系的研究进展.pdf

812 · · 中国肺癌杂志2 0 1 4 年 1 1月第 1 7卷第 1 1期 Chin J Lung Cancer, November 2014, Vol.17, No.11 DOI: 10.3779/j.issn.1009-3419.2014.11.07 · 综 述 · 肿瘤细胞代谢与肿瘤转移相互关系的 研究进展 张亚龙 房念珍 尤嘉琮 周清华 【 】肿瘤细胞长期处于应激的微环境中，细胞内营养物质及能量的流通速率往往高于正常细胞，肿瘤细 摘要 胞代谢以此为肿瘤转移提供生物合成原料和能量。在转移性肿瘤中也发现糖代谢异常活跃、脂肪酸过度累积等异于 正常细胞的代谢反应。已有研究证实对肿瘤细胞代谢进行调节可影响肿瘤转移，部分成果已应用于临床治疗，靶向 肿瘤细胞代谢是抗肿瘤转移的一个积极有效的方向。本文对目前肿瘤细胞代谢与肿瘤转移相互关系和调节机制的研 究进展进行综述。 【关键词 】 肿瘤；肿瘤细胞代谢；肿瘤转移 Advances in the Relationship Between Tumor Cell Metabolism and Tumor Metastasis Yalong ZHANG, Nianzhen FANG, Jiacong YOU, Qinghua ZHOU Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China Corresponding author: Jiacong YOU, E-mail: yyjjcc_nk@163.com Qinghua ZHOU, E-mail: zhouqh135@163.com Abstract Intracellular nutrients and the rate of energy flowing in tumor cells are often higher than that in normal 【 】 cells due to the prolonged stress of tumor-specific microenvironment. In this context, the metabolism of tumor cells provides the fuel of bio-synthesis and energy required for tumor metastasis. Consistent with this, the abnormal metabolism such as extremely active glucose metabolism and excessive accumulating of fatty acid is also discovered in metastatic tumors. Previous Studies have confirmed that the regulation of tumor metabolism can affect the tumor metastasis, and some of these have been successfully applied in clinical effective,