吩噻嗪类药物引起精神分裂症患者高甘油三酯异常的机制研究.docVIP

???? 吩噻嗪类药物引起精神分裂症患者?高甘油三酯异常的机制研究 ???? ???? 摘要　目的:探讨用吩噻嗪类药物治疗后的慢性精神分裂症患者血高甘油三酯异常特征的危 险因素。方法:采用酶法对113例精神分裂症患者、25例脑器质性精神障碍患者和100 例健康人血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)的水平进行了对 比分析。结果:血高TG与低HDL-C浓度的变化为精神分裂症患者最显著的脂质异常特 征，其中阴性症状组和脑器质性精神障碍患者TG含量明显高于阳性症状组(P0.01) 。结论:长时间服用吩噻嗪类药物引起的高TG和低HDL-C有致动脉粥样硬化(AS)的作用，尤其是阴性症状和脑器质性精神障碍患者可加重 认知功能的损害，高TG与HDL-C水平呈负相关是诱发缺血性心血管疾病的危险生物学因素。关键词　精神分裂症；甘油三酯；高密度脂蛋白胆固醇；吩噻嗪类分类号：R971+.4　　文献标识码：A　　文章编号：1001-5213(2000)07-0389-03 Research on abnormal serum triglyceride in patients with schizophrenics Wen Fang,Cheng Zili(First Affilited Hosptal of Hubei Medical University,Wuhan 430060) ABSTRACT　OBJECTIVE：To study the risk factors of hypertriglyceridemia abnormal ch aracter in patients with chronic schizophrenia after therapy receiving phenothia zine drugs.METHODS：Using enzyme methods,the serum levels of triglyceride(T G).High-density lipoprotein cholesterol(HDL-C),total cholesterol(TC) level in 138 schizophrenia patients and 100 normal controls were analysed. RESULTS：The changes of high TG and low level HDL-C were the mo st significant lipid normal character of schizophreniacs serum TG of brain organ ic schizophreniacs and the negative patients were significiantly higher than tho se of the postive patients(P0.01),but levels of TC werent different fr om the normal controls(P0.05). CONCLUSIONS：High TG low HDL-C due to long taking phenothiazine drugs can lead to arteriosclerosis,especially in the organic and negative schiz ophreniacs which can make their abnormaties of cognitive function,the negative c orrelation of high TG and low HDL-C is a biological risk factor of ischemic dis ease for heart and brain.KEY WORDS　schizophrenia;triglyceride;high-density lipoprotein cholesterol;phenothiazine 　　血中脂质异常是动脉粥样硬化(AS)发生、发展的重要因素。近年来已有大量的实验研究重新 评价高甘油三酯(TG)血症的致AS的作用［1］。血高TG反应可以导致产生致病性强、 小颗粒致密的低密度脂蛋白(small dense LDL,sLDL)生成增多，sLDL是致AS的重要因素并有 促粥样斑块破裂的作用。许多疾病与高TG有关。因此，我们在研究吩噻嗪类药物所致精神分 裂症患者血脂代谢紊乱的病理生物学基础上［2.3］，又对113例服用吩噻嗪药物患者 引起高TG水平的可能机制进行探讨，现将实验结果报道如下。 1　资料和方法 1