（整理）Th1-Th2-表面标志.pptVIP

New data suggest that OX40L may play a role in inducing inflammatory cytokines (TNF) J. Exp. Med. 202:1213. 2005 Regulatory T cells in the periphery Naturally occurring CD4+ CD25+ Tregs; develop in thymus Tr1 cells - produce IL-10; induced following interaction with DC in presence of immunsuppressive cytokines Th3 cells - produce IL-10 and TGF-b, usually found at mucosal surfaces * * * * * * * * T helper subsets Penny Morel March 23, 2007 4-0343, morel@pitt.edu Outline Th cell subsets Role of DCs in determining T cell effector function Factors necessary for Th1/2 differentiation A new Th