药物传输中的有序介孔材料-.docVIP

Review Ordered mesoporous materials for drug delivery Shaobin Wang Department of Chemical Engineering,Curtin University of Technology,GPO Box U1987,Perth,WA 6845,Australia a r t i c l e i n f o Article history: Received 16February 2007 Received in revised form 2July 2008Accepted 3July 2008 Available online 9July 2008 Keywords: Mesoporous materials Drug delivery Stimuli-responsive controlled-release Kinetics a b s t r a c t In recent years,mesoporous materials,which have unique pore size,higher surface area and pore volume,have been widely employed as carriers for controlled drug delivery.Compared with amorphous colloidal and porous silica,mesoporous silicas exhibit higher loading of drugs and provide a controlled drug release if modi?ed by functionalisation.In this paper,we review the research work in this area discussing the textural and structural properties of several mesoporous materials such as M41S,SBA,MSU,and HMS in drug loading and release pro?le.The in?uence of functionalisation of mesoporous materials by organ-ics is also discussed.Two systems of drug delivery mechanism,sustained release and stimuli-responsive controlled-release,are compared and drug release kinetics is described.Bioactivity of various mesopor-ous solids is also presented. ó2008Elsevier Inc.All rights reserved. Contents 1.Introduction 12. Drug/mesoporous-silica systems for sustained release of various drugs 22.1.M41S based mesoporous materials 22.2.SBA-based mesoporous materials32.3.HMS-based mesoporous materials42.4.MSU-based and other mesoporous materials 43. Drug release profile and the kinetics 43.1.Effect of factors influencing the drug release 43.2.Kinetics of drug release54.Stimuli-responsive control release system65.Biocompatibility of mesoporous silica/drug system76. Summary and perspectives 8References (9 1.Introduction Over the past three decades,there has been rapid growth in the area of drug delivery,in searching of new drug delivery systems (NDDS.Both natural and synthetic m