2.3病理生理学病理生理学.pdf

03 靶点的分类 aa 靶点分类 (Classification of Drug Targets) 核受体, 2% 其他, 7% 核酸, 2% 细胞膜受体, 离子通道, 45% 5% 细胞因子/激 素, 11% 酶, 28% 药物靶点举例 —— 细胞膜受体 类型 药物活性 举例 Direct ligand-gated ion channel receptors GABAA receptors Barbiturate binding site agonists Barbiturate Benzodiazepine binding site agonists Benzodiazepines Acetylcholine receptors Nicotinic receptor agonists levamisole Nicotinic receptor depolarizing Suxamethonium antagonists Nicotinic receptor allosteric Galantamine modulators Glutamate receptors (ionotropic) NMDA subtype antagonists Memantine NMDA subtype phencyclidine Ketamine 复旦大学药学院 binding site antagonists 药物靶点举例 —— 细胞膜受体 类型 药物活性 举例 G-protein-coupled receptors Acetylcholine receptors Muscarinic receptor agonists Pilocarpine Muscarinic receptor antagonists Tropane derivatives Adenosine receptors Adenosine A1 Caffeine receptor antagonists