细环病毒-从实验室到临床ppt参考课件.ppt

* * * * 细环病毒：从实验室到临床 Torquetenovirus: the human virome from bench to bedside 文献汇报 * 2020/3/15 TTV: Transfusion transmitted virus or Torquetenovirus From torques and tenuis, Latin for ‘necklace’ and ‘thin,’ respectively 输血后肝炎（肝中病毒载量是血中的10-100倍，并且与血清ALT升高相关）【现已否定该结论】 Human virome at least 29 major species 细环病毒：首个被发现的单链环状DNA病毒 * 2020/3/15 TTV prevalence 95% in most cases independent of age, socioeconomic standing and health conditions 来源：胎盘、呼吸道、输血 分布：T淋巴细胞 现有临床应用： TTV as a Marker of Anthropic Pollution TTV as a Marker of Immune Status Orphan virus~孤儿病毒（非病原性病毒） * 2020/3/15 检测水源是否被污染： 现有方法为检测细菌，但是很容易出现假阳性 某些情况下即使细菌检测为阴性也不能排除被污染 检测病毒更准确 TTV分布广泛：医院空气、物件表面均可存在 TTV as a Marker of Anthropic Pollution TTV as a Marker of Immune Status 免疫功能完整性： the ability to mount a protective immune response against an antigenic stimulation. 现有检测：抗原特异性，抗原非特异性；检测繁琐，检测方法缺乏标准化 TTV与CD8+57+T淋巴细胞比例成负相关 对抗病毒药不敏感 * 2020/3/15 TTV as a Marker of Immune Status excessive (too many opportunistic infections and cancers) inadequate (too many episodes of cellular acute rejection) Maintenance immunosuppression * 2020/3/15 * * * *