药学服务对提高慢性乙型肝炎患者用药依从性的效果影响.docVIP

药学服务对提高慢性乙型肝炎患者用药依从性的效果影响 【摘 要】 目的：探究药学服务前后对提高慢性乙型肝炎(CHB)患者抗乙肝病毒药物用药依从性的影响。方法：定期给 CHB 患者用药宣教和指导，并参与临床医生完善诊疗方案，针对患者给予个体化药学服务;比较药学服务前后CHB 的用药认知度、病毒载量的控制、用药依从性的差异，以及患者对药学服务的需求。结果：药学服务后 12 月， 患者对抗乙肝病毒药物的认知度、药学服务的需求和用药依从性明显提高，病毒载量也得到了有效控制。结论：药学服务的参与提高了 CHB 患者抗乙肝病毒药物用药的认知度和治疗的依从性，对降低了病毒载量(HBV-DNA) 具有积极的临床意义。 【关键词】 药学服务;抗乙肝病毒药物;病毒载量(HBV-DNA);用药依从性 【中图分类号】 R 969.3 【文献标志码】 A 【文章编号】 1672-787(8 2019)04-637-004 Influence of Pharmaceutical Care on Improving Medication Compliance in Patients with Chronic Hepatitis B YANG Sai-zhen*1, CHEN Jie*2, LIU Zhang, YU Ming-liKunming No.3 Peoples Hospital, kunming 650041, ChinaABSTRACT Objective: To explore the effect of pharmaceutical care before and after on the improvement of anti- HBV drug compliance in chronic hepatitis B (CHB) patients. Methods: Regular medication instruction and guidance for CHB patients, and participating in clinical doctors to improve the diagnosis and treatment program, and providing in- dividual pharmaceutical care for patients; comparing the difference before and after the pharmaceutical care of the pa- tients medication awareness, the viral load control, the medication compliance of CHB, and the demands for pharmaceu- tical care. Results: After 12 months of pharmaceutical care, the patients awareness of anti- hepatitis B drugs, the de- mands for pharmaceutical care and the compliance with medication were significantly improved, and the viral load was effectively controlled. Conclusion: The participation of pharmaceutical care improves the awareness and compliance of CHB patients with anti-HBV drugs, and has a positive clinical significance in reducing the viral load (HBV-DNA). KEY WORDS pharmaceutical care; anti-hepatitis B drugs; viral load (HBV-DNA); medication com- pliance[Anti Infect Pharm, 2019, 16(04): 637-640] 我国作为世界第一人口大国，据 WHO 的统计，每年约 100 万人死于肝癌、肝硬化或肝功能衰竭。在我国，肝癌、肝硬化或肝功能衰竭常与乙型肝炎病毒(HBV)感染有关，目前，我国约 3.5 亿 HBV 携带者[1]。慢性乙型肝炎(CHB)患者需要长期甚至终生抗病毒药物治疗，而用药的依从性是影响治疗效果的关键因素之一。故 CHB 患者用药依从