奥沙利铂联合替吉奥对结肠癌患者血清炎症因子及不良反应的影响.docxVIP

奥沙利铂联合替吉奥对结肠癌患者血清炎症因子及不良反应的影响 陆小锋 朱渊东 吴深宝 [摘要] 目的 探讨奥沙利铂联合替吉奥对结肠癌患者血清炎症因子及不良反应的影响。 方法 选取我院20XX年1月～20XX年2月收治的100例结肠癌患者，采取随机原则，将入选对象分为研究组和对照组，每组50例，对照组患者采取奥沙利铂治疗，研究组患者采取奥沙利铂联合替吉奥治疗，对比两种治疗方案对结肠癌患者治疗效果、血清炎症因子及不良反应的影响。 结果 研究组患者的治疗总有效率明显高于对照组（P0.05）;两组患者治疗前血清炎症因子（TNF-α、IL-6、IL-8、IL-10）水平对比，差异无统计学意义（P0.05），经治疗，两组患者治疗后各项炎症因子水平有所降低，而研究组患者治疗后炎症因子表达水平明显低于对照组（P0.05）;两组患者不良反应发生率对比，差异无统计学意义（P0.05）。 结论 奥沙利铂联合替吉奥治疗结肠癌可较好降低血清炎症因子水平，降低不良反应发生率，安全性好，值得临床上推广应用。 [关键词] 奥沙利铂;替吉奥;结肠癌;血清炎症因子;不良反应 [中图分类号] R735.35 [文献标识码] B [文章编号] 1673-9701（2020）09-0036-04 [Abstract] Objective To investigate the effects of oxaliplatin combined with tigio on serum inflammatory factors and adverse reactions in patients with colon cancer. Methods One hundred patients with colon cancer treated in our hospital from January 20XX to February 20XX were selected and randomly divided into study group and control group， with 50 cases in each group. Patients in the control group were treated with oxaliplatin， and patients in the study group were treated with oxaliplatin combined with tigio. The effects of the two treatment regimens on clinical effect， serum inflammatory factors and adverse reactions in patients with colon cancer were compared. Results The total treatment efficiency of the study group was significantly higher than that of the control group（P0.05）. There was no significant difference in serum inflammatory factors（TNF-α， IL-6， IL-8， IL-10） levels between the two groups before treatment（P0.05）. The levels of various inflammatory factors in the two groups decreased after treatment， while the expression levels of inflammatory factors in the study group were significantly lower than those in the control group（P0.05）. There was no statistical difference in the incidence of adverse reactions between the two groups（P0.05）. Conclusion Oxaliplatin combined with tigio in the treatment of colon cancer can well reduce serum inflammatory factor levels， reduce the incidence of advers