含西藏温泉水的修护霜对敏感性皮肤辅助治疗作用的临床观察.docxVIP

含西藏温泉水的修护霜对敏感性皮肤辅助治疗作用的临床观察 Preliminary Observation on the Effect of Repairing Cream Containing Tibetan Thermal Spring Water on Sensitive Skin WANG Qian，LI Yong，XIAN Yan，WANG Ying，WEN Xiang （Department of Dermatology，West China Hospital，Sichuan University，Chengdu *****，Sichuan，China） Abstract： Objective To evaluate the effect and safety of repairing cream（trade name： Biorrier Anti-sensitive Repairing Cream ） containing Tibetan thermal spring water on sensitive skin. Methods Subjects used the Biorrier Anti-sensitive Repairing Cream once in the morning and evening for 28 days. Lactic acid stinging scores were noted before enrollment and at the end of the trial. Evaluations were performed before enrollment and on the 1st，7th，and 28th day of enrollment， including the skin image uptake （VISIA），stratum corneum hydration， and transepidermal water loss （TWEL），subjective evaluations of skin lesions and adverse reactions were recorded by the same doctor and patients. Results 34 patients were enrolled，1 patient was lost to follow-up， and 3 patients were withdrawn due to irritation and 30 patients completed the trail.There were statistically significant differences in the total scores of lactic acid stinging values between enrollment and the time of the last follow-up at 2.5 min， 5 min， and the sum of the two time periods（P0.05）.There was significant difference between both patients and doctors subjective evaluations（P0.05）.3 cases presented erythema， itching，tingling，the incidence rate was 8.82%， all relieved after discontinuation of use. Conclusion Biorrier Anti-sensitive Repairing Cream has a certain adjuvant effect on sensitive skin. Key words： sensitive skin;thermal spring water;lactic acid stinging test;non-invasive objective quantitative detection;subjective evaluation 近年來，随着环境的污染、生活压力增大、化妆品的不良使用等因素导致敏感性皮肤的发病率居高不下。根据2017中国敏感性皮肤诊治专家共识认为，敏感性皮肤是皮肤在生理或病理条件下的一种高反应状态，主要表现为易出现灼热、刺痛、瘙痒以及紧绷感等主观症状，伴或不伴红斑、鳞屑，毛细血管扩张等客观体征。临床中治疗敏感性皮肤以抗炎、舒敏、保湿及修复为主。本