株嗜麦芽窄食单胞菌感染的临床及抗菌药物使用分析.docVIP

183株嗜麦芽窄食单胞菌感染的临床及抗菌药物使用分析 薛洪源-侯天文珥1.片求恩国际和平医院临床药学室，河北 石家庄050082； 2.白求恩国际和平医院检 验科，河北 石家庄050082) 目的:分析和总结183株嗜麦芽窄食单胞菌的感染情况和对抗菌药的耐药情况，为临床预防和治疗该菌引起 的感染提供依据。方法:对临床标本屮分离的183株嗜麦芽窄食单胞菌进行细菌鉴定和药敏试验，复习有关 临床资料，分析发病的危险因素。结果：183株嗜麦芽窄食单胞菌的检出标本以痰为主，占81.2%；居检出 临床科室前4位的依次为呼吸科(31.8%)、老干部科(24.7%)、ICU病房(17.6%)、肿瘤科(5.9%)； 高龄、侵入性诊疗操作、使用广谱抗菌药为嗜麦芽窄食单胞菌感染的危险因索，分别占80.0%、41.8%、 100%； 183株对常用抗菌索耐药，敏感率超过50%的抗菌药依次为复方磺胺甲噁哇(80.3%)、头葩哌酮钠 /舒巴坦(69.9%)、哌拉曲林/他哇巴坦(64.5%)、环丙沙星(57.4%)。结论:嗜麦芽窄食单胞菌感染多发生 在有各种基础疾病、免疫力低的患者，该菌耐药现象严重，治疗应根据药敏试验结果合理选丿IJ抗菌药。 [关键词]细菌，嗜麦芽窄食单胞菌，感染，抗生索 Analysis of clinical characteristics and drug sensitivity tests of 183 strains of infection by stenotrophomonas maltophilia Xuehongyuan , Houtia nwen“ (1. Dep ? of Pharmacology； 2.Dep ? of Clinical Laboratory, Beth une International Peace Hospital, Shijiazhuang 050082, China) [Abstract] Objective: To analyse the situation of epidemic and antibiotic resistance of Stenotrophomonasmaltophilia in order to provide basis for the prevention and treatment of the infection indused by the bacterium. Methods: 183 strains of Stenotrophomonasmaltophilia from clinical isolates were identified and their susceptibility was tested. Clinical data were reviewed, and risk factors were analysized. Results: Most of 183 strains were isolated from sputum (81.2%) . 183strains were mainly isolated from department of respiratory medicine (31.8%) , ICU (17.6%) , department of cadre (24.7%) , and department of oncology (5.9%) . Risk factors was old age, invasive procedures and the use of broad spectrum antibiotics, account for 80.0%, 41.8% and 100%, respectively. The drug sensitivity tests in vitro showed that these strains were resistant to commonly used antibiotics, and dmgs whose sensitive rate was over 50% included SMZ-TMP (80.3%) , cefoperazone-sulbactam (69.9%) , piperacillin-tazobctam (64.5%) , and ciprofloxacin (57.4%)? Conclusion: The infection caused by Stenotrophomonasmaltophilia often occur in patients with severe underlying diseases and low immunity. St