来曲唑-芳香化酶抑制剂讲解.pptVIP

Clinical use The study group consisted of 29 infertile men with a low serum T/E2 ratio (10) . Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Aromatase inhibitors in men 概要 Background 1 Safety and concerns 5 Aromatase inhibitors 3 Aromatase 2 Effects of aromatase inhibitior 4 Background The role of estradiol ? gaining and maintaining bone mass ? closing of the epiphyses ? the feedback on gonadotropin secretion Estrogen excess ? premature closure of the epiphyses ? gynecomastia ? low gonadotropin ? low testosterone levels. 5/30/2019 Aromatase Aromatase Aromatase, also known as estrogen synthetase, is the key enzyme in estrogen biosynthesis . The enzyme, localized in the endoplasmic reticulum of the estrogen- producing cell, is encoded by the CYP19A1 gene ， which is localized on chromosome 15 and comprises nine exons ， the start codon for translation is located on exon 2. CYP19 gene ? Men with estrogen deficiency caused by a mutation in the CYP19 gene suffer from ： I. low bone mineral density (BMD) II. unfused epiphyses, III. high gonadotropin IV. high testosterone levels . Aromatase activity ? gonads ? placenta ? brain ? fat tissue ? muscle ? hair ? bone ? vascular tissue It has been demonstrated in: Estradiol production ? direct testicular secretion ? conversion of testicular androgens ? peripheral conversion of adrenal androgens 5/30/2019 Aromatase inhibitors Mechanism Nonsteroidal enzyme inhibitors such