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第6节 Protective Groups in Organic Synthesis
Peptide Synthesis
肽键(酰胺键)
1969:
B. Gutte; R. Hirschmann
首次合成了含有120个氨基酸的enzyme
(活性仅为天然的1%~13%)
论文分别于Nov. 25th 和Dec. 19th , 1968寄到JACS ;
January 15th , 1969即刊发在JACS上。
“A protein molecule with true enzymatic activity
A record! toward its natural substrate can be totally
synthesized.”
1
2
Total synthesis of an enzyme. I. Objective and strategy
Robert G. Denkewalter, Daniel F. Veber, Frederick W. Holly, and Ralph
Hirschmann pp 502 - 503; DOI: 10.1021/ja01030a051
Total synthesis of an enzyme. II. Synthesis of a protected
tetratetracontapeptide corresponding to the 21-64 sequence of ribonuclease A
Robert G. Strachan and et al. pp 503 - 505; DOI: 10.1021/ja01030a052
Total synthesis of an enzyme. III. Synthesis of a protected hexacontapeptide
corresponding to the 65-124 sequence of ribonuclease A
Susan R. Jenkins and et al. pp 505 - 506; DOI: 10.1021/ja01030a053
Total synthesis of an enzyme. IV. Factors affecting the conversion of
protected S-protein to ribonuclease S
Daniel F. Veber, Sandor L. Varga, John D. Milkowski, H. Joshua, John B. Conn,
Ralph Hirschmann, and Robert G. Denkewalter pp 506 - 507; DOI:
10.1021/ja01030a054
Total synthesis of an enzyme. V. Preparation of enzymatically active material
Ralph Hirschmann, Ruth F. Nutt, Daniel F. Veber, Ronald A. Vitali, Sandor L. Varga,
Theodore A. Jacob, Frederick W. Holly, and Robert G. Denkewalter
pp 507 - 508; DOI: 10.1021/ja01030a055
JACS 1969, 91, iss 2, published on 15th Jan, 1969
3
如何形成一个肽键?
the use of acyl chlorides in peptide synthesis is rare because of t
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