高等有机合成：第6节 Protective Groups in Organic Synthesis.pdfVIP

第6节 Protective Groups in Organic Synthesis Peptide Synthesis 肽键（酰胺键） 1969: B. Gutte; R. Hirschmann 首次合成了含有120个氨基酸的enzyme （活性仅为天然的1%~13%） 论文分别于Nov. 25th 和Dec. 19th , 1968寄到JACS ； January 15th , 1969即刊发在JACS上。 “A protein molecule with true enzymatic activity A record! toward its natural substrate can be totally synthesized.” 1 2 Total synthesis of an enzyme. I. Objective and strategy Robert G. Denkewalter, Daniel F. Veber, Frederick W. Holly, and Ralph Hirschmann pp 502 - 503; DOI: 10.1021/ja01030a051 Total synthesis of an enzyme. II. Synthesis of a protected tetratetracontapeptide corresponding to the 21-64 sequence of ribonuclease A Robert G. Strachan and et al. pp 503 - 505; DOI: 10.1021/ja01030a052 Total synthesis of an enzyme. III. Synthesis of a protected hexacontapeptide corresponding to the 65-124 sequence of ribonuclease A Susan R. Jenkins and et al. pp 505 - 506; DOI: 10.1021/ja01030a053 Total synthesis of an enzyme. IV. Factors affecting the conversion of protected S-protein to ribonuclease S Daniel F. Veber, Sandor L. Varga, John D. Milkowski, H. Joshua, John B. Conn, Ralph Hirschmann, and Robert G. Denkewalter pp 506 - 507; DOI: 10.1021/ja01030a054 Total synthesis of an enzyme. V. Preparation of enzymatically active material Ralph Hirschmann, Ruth F. Nutt, Daniel F. Veber, Ronald A. Vitali, Sandor L. Varga, Theodore A. Jacob, Frederick W. Holly, and Robert G. Denkewalter pp 507 - 508; DOI: 10.1021/ja01030a055 JACS 1969, 91, iss 2, published on 15th Jan, 1969 3 如何形成一个肽键? the use of acyl chlorides in peptide synthesis is rare because of t