机体防御与免疫：第11章 抗原提呈细胞与抗原加工及提呈.pptVIP

1. 内源性抗原的加工提呈 蛋白酶体 (含PSMB) 降解 degraded by proteasome 胞浆蛋白 (cytosolic protein) 短肽 (peptide) 1. 内源性抗原的加工提呈 蛋白酶体 (含PSMB) 降解 degraded by proteasome 胞浆蛋白 (cytosolic protein) 短肽 (peptide) TAP转运(选择性8-13个氨基酸) transported by TAP 进入内质网 (endoplasmic reticulum, ER) 1. 内源性抗原的加工提呈 蛋白酶体 (含PSMB) 降解 degraded by proteasome 胞浆蛋白 (cytosolic protein) 短肽 (peptide) TAP转运(选择性8-13个氨基酸) transported by TAP 进入内质网 (endoplasmic reticulum, ER) MHC I与肽结合形成复合物 associated with MHC class I 1. 内源性抗原的加工提呈 蛋白酶体 (含PSMB) 降解 degraded by proteasome 短肽 (peptide) TAP转运(选择性8-13个氨基酸) transported by TAP 进入内质网 (endoplasmic reticulum, ER)