偏头痛的病生理简介讲义.ppt

偏头痛的头痛机制 头部疼痛结构 Ray BS, Wolff HG. Experimental studies on headache. Pain-sensitive structures of the head and their significance in headache. Arch Surg. 1940;41:813-856. 在神经外科手术病人志愿者里，刺激脑膜中动脉引起同侧颞部头痛。 三叉血管神经通路 Daniela Pietrobon Patholphysiology of migraine. Annu.Rev.Physiol.2013.75:365-91 TCC的结构解释了偏头痛的颈痛现象 颅内血管神经支配 Lars Edvinsson Basic mechanisms of migraine and its acute treatment. Phar.Ther. 136(2012) 319-33. 血管神经单元是三叉血管神经系统激活的基础。 CSD激活三叉血管神经系统 外周激活 Lars Edvinsson Basic mechanisms of migraine and its acute treatment. Phar.Ther. 136(2012) 319-33. 激活的神经末梢释放神经肽：CGRP，P物质等，引起血管扩张，血管扩张刺激神经肽释放，引起快