细胞基因组学在临床中的应用.pptxVIP

Clinical Application of Cancer Cytogenomics;细胞基因组（ Cytogenomics ）;细胞基因组、细胞基因组标志;;;Agilent G2565AA Microarray Scanner System at MDACC;细胞基因组疾病;非肿瘤细胞基因组疾病;Contiguous gene syndrome/ microdeletion syndrome;;智力低下 /aCGH -Who need the test? ? Individuals with unexplained developmental/intellectual delay;Agilent: 580 Kb deletion 2p22.3;;FISH with a red-labeled;;Acute Leukemia in DS;Acute leukemia in Down syndrome; 细胞基因组标志在肿瘤的诊断、 预后、随访跟踪、治疗上的临床应用 ? 血液肿瘤 ? 淋巴瘤 ? 骨髓瘤 ? 白血病;? 诊断;;t(8;14) karyotype;;;t(9;22)(q34;q11.2) - CML;Cryptic t(9;22);Interferon a Gleevec;;Subtype;- 急性淋巴细胞白血病 acute lymphoblastic leukemia;Pediatric ALL;Diagnosis;;Tumors;Probes;SYT/18q11.2 positive in Synovial Sarcoma;Probes;SYT/18q11.2/ Synovial Sarcoma;肿瘤细胞基因组学;预后; 肿瘤预后应用 ? ASS loss in t(9;22) positive CML associated with resistance to interferon therapy;Trisomy 11 as the sole abnormality in MDS;CLL FISH panel;AML1 Amplification in AML;MLL Amplification;T(4;14)(p16;q32) in myeloma;ASS deletion in CML;图片录用于江西省妇幼保健院 李隆玉教授;;治 疗 （ THEAPEUTICS ）;酒窝征 (A) ，橘皮征（ B) ，炎性乳腺癌（ C) ，湿疹样癌 （ D);Her2 amp/Herceptin;PDGFRA rea/Greevec;ALK, ROS1, RET rea in lung cancer;C-MET amp/ARQ197, MP470;新研发;Cancer Cytogenomic;ELL (eleven nineteen lysin rich leukemia gene);MLL;Comparison;B-ALL with t(14;19)(q32;p13.1);Pt;It is a challenge to identify the subtle;;Home-brew FISH EPOR probe;Labeling the FISH Probes;Clinical Features;After IGH confirmation, Where is partner to match? t(1;19)(q23;p13.3) t(11;19)(q23;p13.3) E2A ENL*;? Male ? 6 months old ? Dx with ALL ? B-cell markers including CD10+, CD19+ ? BMT ? Survival 6 mons;Plasma Cell Myeloma;;;;;;;遗传咨询;Clinical Integrated;Genomic Analysis by Array Comparative Genomic Hybridization of Primary Myelofibrosis with Isolated del(13q) Gary Lu, 1 Keyur P. Patel, 1 Roberto N. Miranda, 1 L Jeffrey Medeiros, 1 Tianjian Chen, 2 Bal Mukund Mishra, 1 Ronald Abraham, 1 Ramya Muddasani, 1 Meenakshi Mehrotra, 1 and Raja Luthra 1;