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实验六粪便标本分离-IV
学生讨论课-II
1、讨论课3 :布鲁菌
2 、讨论课4 :炭疽芽孢杆菌
3 、讨论课5 :鼠疫耶尔森菌
4 、操作:药敏试验结果观察
5 、操作:氧化酶试验;生化试验结果观察
动物源性细菌
人兽(畜)共患病
布鲁菌属:布鲁菌
耶尔森菌属:鼠疫杆菌
需氧芽孢杆菌属:炭疽杆菌
布鲁菌属Brucella
-
G , mostly coccobacilli, BSL-3 (potential bioweapon)
• Highly adapted to parasitic, intracellular life style
• Smooth (virulent) vs. rough phenotypes
• Transmission through ingestion of unpasteurized milk and milk products,
close contact with infected animal, tissue or fetus, and via aerosol
• Animal brucellosis: abortion, epididymitis 附睾炎(sterility)
• Human brucellosis:
Insidious onset with unspecific symptoms;
Malta fever, undulant fever…;
Lymphadenopathy, splenomegaly, osteomyelitis and possible
gastroenterological and nervous symptoms, but no abortion;
Chronic infection is culture-negative and difficult to diagnose or prove.
• Two chromosomes, with no plasmid, no lysogenic phages; sensitive to many
common antibiotics, but successful treatment requires prolonged use
• Effective attenuated smooth strain vaccine for animals
• Eradication in livestock possible through effective vaccination and culling;
endemic circulation might select for higher transmissibility and pathogenicity
• Species identified in wild and sea mammals might pose risks as emerging
pathogens
芽孢杆菌属Bacillus
G+ rods, square ends, long chains in culture, central spores
Aerobic. Gelatinase gelatin liquefaction invasiveness
B. anthracis
•Spores in environment herbivores humans; bioweapon
•pXO2 antiphagocytic poly-D-Glu capsule synthesis virulence
•pXO1 toxins (PA, EF, LF); PA + EF = ET; PA + LF = LT
•Cutaneous anthrax (~95%):
Pruritic papule vesicle(s) necrotic ulcer with central black eschar
healing through granulation leaving scar;
Edema, lymphangitis, lymphadenopathy; fever, malaise, headache;
Seps
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