免疫相关的信号转导.pptVIP

T cell Signaling Downstream of PLCg1 (2) * PPT课件 T cell Signaling Downstream of PLCg1 (3) * PPT课件 Activation of Transcription Factors in T Cells * PPT课件 * PPT课件 * PPT课件 Mechanisms of T cell Stimulation by CD28 * PPT课件 The B7 and CD28 Families * PPT课件 Role of Cbl-b in Terminating T cell Responses Cbl-b: ubiquitin ligase * PPT课件 B cell Antigen Receptor Complex 二、BCR-Igα/Igβ介导的信号转导 * PPT课件 Signal transduction by the BCR complex * PPT课件 Role of Complement in B cell Activation * PPT课件 * PPT课件 （四）NF-?B通路 NF-?B是一种几乎存在于所有细胞的转录因子，广泛参与机体防御反应、组织损伤和应激、细胞分化和凋亡以及肿瘤生长抑制等过程。 肿瘤坏死因子受体（TNF-R）、白介素1受体等重要的促炎细胞因子受体家族所介导的主要信号转导通路之一是NF-?B（nuclear factor-?B，NF-?B）通路。 * PPT课件 NF-?B 信号转导通路 * PPT课件 第二节 固有免疫相关的信号转导 一、Toll样受体相关的信号通路 二、NOD样受体相关的信号通路 * PPT课件 * PPT课件 Cellular Location of Innate Immune Receptors * PPT课件 Structure, Location, and Specificities of TLRs 一、Toll样受体相关的信号通路 * PPT课件 The 2011 Nobel Prize in Physiology or Medicine was divided, one half jointly to Bruce A. Beutler and Jules A. Hoffmann for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity. (1957- ) Bruce A. Beutler Ralph M. Steinman (1943 – September 30, 2011) (1941- ) Jules A. Hoffmann 2011 * PPT课件 Signaling functions of TLRs (1) * PPT课件 Signaling functions of TLRs (2) * PPT课件 * PPT课件 二、NOD样受体相关的信号通路 NOD样受体（NOD like receptor, NLR)是一类含有核苷酸结合寡聚域（nucleotide-binding oligomerzalition domain,NOD)的蛋白质家族，存在于细胞浆。 * PPT课件 ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? The effector domains found in NLRs?are?CARDs,?pyrin domains (PYDs), baculoviral inhibitor of apoptosis repeat?(BIR) domains, or the transactivator domain (AD). * PPT课件 NLR signaling * PPT课件 The Inflammasome * PPT课件 第三节 适应性免疫应答相关的信号转导 一、TCR-CD3介导的信号转导 二、BCR-Igα/Igβ介导的