药理学试卷3知识点.docVIP

2004级英语医学专业、2005级口腔七年制药理学期末考试试题（A卷） 一、名词解释（每题2分，共10分） 1．Half life 2．First-order kinetics 3．Bioavailability 4．Drug resistance 5．Superinfection 二、选择题（A型每题0.8分，X型每题1分,共60分） （一）Type A choice questions (only one answer is correct) 1. A drug with t1/2 3 hours is given intravenously, the steady state of plasma concentration can be expected within A. 3 hrs B. 8 hrs C. 10 hrs D. 15 hrs E. 20 hrs 2. Which of the following statements is correct? A. weak bases are absorbed efficiently across the epithelial cells of the stomach B. coadministration of atropine speeds the absorption of a second drug C. drugs showing large Vd can be efficiently removed by dialysis of the plasma. D. stressful emotions can lead to a slowing of drug absorption. E. if the Vd for a drug is small, most of the drug is in the extraplasmic space. 3. pD2 is A. therapeutic index B. antagonist index C. affinity index D. dissociation constant E. elimination rate constant 4. All of the following statements are true except A. aspirin(pKa 3.5) is 91% in its lipid-soluble, protonated form at pH 2.5 B. the basic drug promethazine (pKa=9.1) is more ionized at pH=7.4 than at pH 2 C. absorption of a weakly basic drug is likely to occur faster from the intestine than from the stomach D. acidification of the urine accelerates the secretion of a weak base, pKa = 8 E. uncharged molecules more readily cross cell membranes than charged molecules 5. Which of the following statements is correct A. if 10mg of drug A produces the same response as 100mg of drug B, drug A is more efficacious than drug B B. the greater the efficacy, the greater the potency of a drug C. in selecting a drug, potency is usually more important than efficacy D. a competitive antagonist increases ED50 E. variation in response to a drug among different individuals is most likely to occur with a drug showing a large therapeutic index 6. Among the following drugs, which will be excreted most quickly in acidic urine？ A. a weak acid drug with pKa of 5.5