东亚钳蝎提取物对癫痫小鼠大脑皮层NMDA受体和GABAA受体的调节作用.docVIP

东亚钳蝎提取物对癫痫小鼠大脑皮层NMDA受体和GABAA受体的调节作用 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：东亚钳蝎提取物对癫痫小鼠大脑皮层NMDA受体和GABAA受体的调节作用 1 1 材料与方法 3 2 结果 5 3 讨论 6 文2：谷氨酸NMDA受体与学习记忆的关系 7 1 NMDA受体的组成与功能 7 2 学习记忆的生理基础 8 3 NMDA受体对学习记忆的双重影响 10 参考文摘引言： 11 原创性声明（模板） 13 文章致谢（模板） 13 正文 东亚钳蝎提取物对癫痫小鼠大脑皮层NMDA受体和GABAA受体的调节作用 文1：东亚钳蝎提取物对癫痫小鼠大脑皮层NMDA受体和GABAA受体的调节作用 The Modulation of Buthus marteic Karch Extract（BmKE）on Cerebral Cortex NMDA Receptor and GABAA Receptor in Epileptic Mice Abstract：ObjectiveTo study the antagonism of BmKE on epilepsy of PTZinduced epileptic mice and the modulation on NMDA receptor(NMDAR) and GABAA receptor (GABAAR) binding activities in cerebral cortex. MethodsThe convulsion latent periods of PTZinduced epileptic mice，vaproate sodium（VAP，positive control drug）treating group and BmKE（L），BmKE（M），BmKE(H) treating groups were observed. NMDAR and GABAAR binding activities of cerebral cortex were detected by isotope 3H-tagged MK-801 and mulimol respectively. ResultsBmKE(M) significantly prolonged laten periods of epileptic mice(P＜), BmKE(L) had a few effect on latent periods, the prolonged value of latent periods treated by BmKE(H) was shorter than that treated by BmKE(M). PTZ significantly increased NMDAR binding activities in cerebral cortex of mice (P＜). Both BmKE(M) and BmKE(H) excessively decreased those of PTZ-induced epileptic mice(p),but those of BmKE(L) treated group had no significant difference with those of PTZinduced epilepsic mice. GABAAR binding activities were reduced by PTZ. (P＜). BmKE(L) and BmKE(H) significantly increased those of PTZinduced epileptic mice(P＜), and BmKE(M) excessively increased those of PTZinduced epileptic mice(P＜).Conclusiouitable BmKE can prolong latent periods of epilepstic mice induced by PTZ, and has an antiepileptic effect. The effects of BmKE may have relatiohip between the inhibition on NMDAR binding avtivities and excitation on GABAAR binding avtivities in cerebral cortex of epileptic mice. Key words：BmK